Immunotherapeutic strategies targeting B cell maturation antigen in multiple myeloma

被引：9
作者：
Fang, Yi [1 ]
Hou, Jian [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Hematol, 160 Pujian Rd, Shanghai 200127, Peoples R China
来源：
MILITARY MEDICAL RESEARCH | 2021年 / 8卷 / 01期
关键词：
B cell maturation antigen; Multiple myeloma; Vaccine; Antibody; CAR T-cells; ANTIBODY-DRUG CONJUGATE; BISPECIFIC CAR-T; PLASMA-CELLS; OPEN-LABEL; BCMA; THERAPY; RECEPTOR; PHASE-1; APRIL; VACCINATION;
D O I：
10.1186/s40779-021-00302-x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Multiple myeloma (MM) is the second most common hematologic malignancy, and is characterized by the clonal expansion of malignant plasma cells. Despite the recent improvement in patient outcome due to the use of novel therapeutic agents and stem cell transplantation, all patients eventually relapse due to clone evolution. B cell maturation antigen (BCMA) is highly expressed in and specific for MM cells, and has been implicated in the pathogenesis as well as treatment development for MM. In this review, we will summarize representative anti-BCMA immune therapeutic strategies, including BCMA-targeted vaccines, anti-BCMA antibodies and BCMA-targeted CAR cells. Combination of different immunotherapeutic strategies of targeting BCMA, multi-target immune therapeutic strategies, and adding immune modulatory agents to normalize anti-MM immune system in minimal residual disease (MRD) negative patients, will also be discussed.
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页数：10
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