Iridium-catalyzed alkenyl C-H allylation using conjugated dienes

被引：35

作者：

Xu, Liangyao ^{[1
]}

Meng, Keke ^{[1
]}

Zhang, Jian ^{[1
]}

Sun, Yaling ^{[1
]}

Lu, Xiunan ^{[1
]}

Li, Tingyan ^{[1
]}

Jiang, Yan ^{[1
]}

Zhong, Guofu ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 311121, Zhejiang, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 66期

基金：

中国国家自然科学基金;

关键词：

ELECTRON-DEFICIENT ALKENES; ALLYLIC CARBONATES; FACILE SYNTHESIS; HYDROARYLATION; ACCESS; ACTIVATION; OLEFINATION; ALKYLATION; 1,3-DIENES; EFFICIENT;

D O I：

10.1039/c9cc04419a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An iridium-catalyzed C-H allylation of acrylamides with conjugated dienes was developed, using NH-Ts amide as the directing group. The ligand-and additive-free protocol provided a convenient and atom economic synthesis of branched 1,4-diene skeletons, enabling the tolerance of a wide scope of functionalities such as OMe, F, Cl, Br and CF3. The utility of this protocol is also demonstrated by a preparative scale, as well as C-H functionalization of artemisic amide. Furthermore, NH-Ts amide was efficiently removed by methylation and hydrolysis procedures to provide 1,4-dienoic acid.

引用

页码：9757 / 9760

页数：4

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