REACTIVE ORGANIC CARBONATES WITH LEAVING GROUP FOR BIOLOGICALLY ACTIVE DIPEPTIDES SYNTHESIS

被引：4

作者：

Segneanu, Adina-Elena ^{[1
]}

Balcu, Ionel ^{[1
]}

Mirica, Marius Constantin ^{[1
]}

Iorga, Mirela Ioana ^{[1
]}

Milea, Marius ^{[2
]}

Urmosi, Zoltan ^{[1
]}

机构：

[1] INCEMC Timisoara, Natl Inst R&D Electrochem & Condensed Matter, Timisoara 300569, Romania

[2] Univ Politehn Timisoara, Fac Ind Chem & Environm Engn, Timisoara 300006, Romania

来源：

ENVIRONMENTAL ENGINEERING AND MANAGEMENT JOURNAL | 2009年 / 8卷 / 04期

关键词：

alkoxycarbonylation; leaving group; N; '-disuccinimidylcarbonate; PEPTIDES;

D O I：

10.30638/eemj.2009.112

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The aim of this present paper is investigation of the reactions of preparation of unsymmetrical reactive carbonates from the corresponding symmetrical carbonates and different type of alcohols. The asymmetrical carbonates represent alternative reagents (mild, efficient) for alkoxycarbonylation of amines and amino-acids. The synthesized compounds were characterized by spectroscopic and chromatographic methods. A general method for preparation of asymmetrical carbonates was develop from N,N '-disuccinimidylcarbonate. The yield of this reactive carbonates depends by alcohols reactivity, hindered factor and stability of final product.

引用

页码：797 / 801

页数：5

共 5 条

[1]

Ghost A. K., 1992, TETRAHEDRON LETT, V32, P2781

[2] Manipulation of unfolding-induced protein aggregation by peptides selected for aggregate-binding ability through phage display library screening [J].

Kundu, B ;

Shukla, A ;

Guptasarma, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 291 (04) :903-907

[3]

Nájera C, 2002, SYNLETT, P1388

[4]

SEGNEANU A, 2007, USING ORGANIC CARBON

[5] Organic carbonates [J].

Shaikh, AAG ;

Sivaram, S .

CHEMICAL REVIEWS, 1996, 96 (03) :951-976

← 1 →