Utilizing Paper-Based Devices for Antimicrobial-Resistant Bacteria Detection

被引：119

作者：

Boehle, Katherine E. ^{[1
]}

Gilliand, Jake ^{[2
]}

Wheeldon, Christopher R. ^{[1
]}

Holder, Amethyst ^{[2
]}

Adkins, Jaclyn A. ^{[1
]}

Geiss, Brian J. ^{[3
]}

Ryan, Elizabeth P. ^{[2
]}

Henry, Charles S. ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

[2] Colorado State Univ, Dept Environm & Radiol Sci, Ft Collins, CO 80523 USA

[3] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 24期

关键词：

antimicrobial resistance; nitrocefin; paper-based analytical devices; beta-lactam antibiotics; beta-lactamase; BETA-LACTAMASE; ANTIBIOTIC-RESISTANCE; ESCHERICHIA-COLI; SUSCEPTIBILITY; WATER; PREVALENCE; SECRETION; GENES;

D O I：

10.1002/anie.201702776

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Antimicrobial resistance (AMR), the ability of a bacterial species to resist the action of an antimicrobial drug, has been on the rise due to the widespread use of antimicrobial agents. Per the World Health Organization, AMR has an estimated annual cost of USD34 billion in the US and is predicted to be the number one cause of death worldwide by 2050. One way AMR bacteria can spread, and by which individuals can contract AMR infections, is through contaminated water. Monitoring AMR bacteria in the environment currently requires that samples be transported to a central laboratory for slow and labor intensive tests. We have developed an inexpensive assay using paper-based analytical devices (PADs) that can test for the presence of beta-lactamase-mediated resistance. To demonstrate viability, the PAD was used to detect beta-lactam resistance in wastewater and sewage and identified resistance in individual bacterial species isolated from environmental water sources.

引用

页码：6886 / 6890

页数：5

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