Possible involvement of soluble B7-H4 in T cell-mediated inflammatory immune responses

被引:33
作者
Kamimura, Yosuke [1 ]
Kobori, Hiroko [1 ]
Piao, Jinhua [1 ]
Hashiguchi, Masaaki [1 ]
Matsumoto, Koichiro [2 ]
Hirose, Sachiko [3 ]
Azuma, Miyuki [1 ]
机构
[1] Tokyo Med & Dent Univ, Grad Sch, Dept Mol Immunol, Bunkyo Ku, Tokyo 1138549, Japan
[2] Juntendo Univ, Sch Med, Dept Pathol, Bunkyo Ku, Tokyo 1138421, Japan
[3] Kyushu Univ, Grad Sch Med Sci, Res Inst Dis Chest, Higashi Ku, Fukuoka 8128582, Japan
关键词
Costimulation; B7; family; Contact hypersensitivity; Mouse; T cells; B7; FAMILY-MEMBER; PROTEIN; LIGAND; EXPRESSION; RECEPTOR; CARCINOMA; APOPTOSIS; PATHWAY; BREAST; CANCER;
D O I
10.1016/j.bbrc.2009.08.144
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
B7-H4, a newly identified B7 family molecule, is reported to regulate T cell activation. However, the expression and function of B7-H4 remain controversial. Here, we demonstrated that B7-H4 expression in immune cells was undetectable at both the transcription and cell-surface protein levels. B7-H4 transfectants augmented anti-CD3 mAb-induced re-directed cytotoxicity and this was inhibited by anti-B7-H4 mAb. In a hapten-induced contact hypersensitivity model, treatment with anti-B7-H4 mAb at sensitization, but not at challenge, efficiently suppressed the ear swelling and CD8(+) T cell activation assessed by CD25 expression and IFN-gamma production. We found that cells expressing B7-H4 secreted soluble B7-H4 and the serum B7-H4 level increased with disease progression in lupus-prone and collagen-induced arthritis autoimmune mice and after the antigen challenge in allergic inflammatory diseases. Our results suggest a different action of B7-H4 in T cell-mediated inflammatory responses and the possible involvement of soluble B7-H4 in inflammatory immune responses. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:349 / 353
页数:5
相关论文
共 26 条
[1]  
Ebata T, 2001, EUR J IMMUNOL, V31, P1410, DOI 10.1002/1521-4141(200105)31:5<1410::AID-IMMU1410>3.0.CO
[2]  
2-H
[3]   Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses [J].
Hashiguchi, Masaaki ;
Kobori, Hiroko ;
Ritprajak, Patcharee ;
Kamimura, Yosuke ;
Kozono, Haruo ;
Azuma, Miyuki .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (30) :10495-10500
[4]   Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis [J].
Iwai, H ;
Abe, M ;
Hirose, S ;
Tsushima, F ;
Tezuka, K ;
Akiba, H ;
Yagita, H ;
Okumura, K ;
Kohsaka, H ;
Miyasaka, N ;
Azuma, M .
JOURNAL OF IMMUNOLOGY, 2003, 171 (06) :2848-2854
[5]   Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation [J].
Iwai, H ;
Kozono, Y ;
Hirose, S ;
Akiba, H ;
Yagita, H ;
Okumura, K ;
Kohsaka, H ;
Miyasaka, N ;
Azuma, M .
JOURNAL OF IMMUNOLOGY, 2002, 169 (08) :4332-4339
[6]   The Glucocorticoid-Induced TNF Receptor-Related Protein (GITR)-GITR Ligand Pathway Acts As a Mediator of Cutaneous Dendritic Cell Migration and Promotes T Cell-Mediated Acquired Immunity [J].
Kamimura, Yosuke ;
Iwai, Hideyuki ;
Piao, Jinhua ;
Hashiguchi, Masaaki ;
Azuma, Miyuki .
JOURNAL OF IMMUNOLOGY, 2009, 182 (05) :2708-2716
[7]   Polymorphism of murine Fas ligand that affects the biological activity [J].
Kayagaki, N ;
Yamaguchi, N ;
Nagao, F ;
Matsuo, S ;
Maeda, H ;
Okumura, K ;
Yagita, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :3914-3919
[8]   B7-H4 expression in renal cell carcinoma and tumor vasculature: Associations with cancer progression and survival [J].
Krambeck, Amy E. ;
Thompson, R. Houston ;
Dong, Haidong ;
Lohse, Christine M. ;
Park, Eugene S. ;
Kuntz, Susan M. ;
Leibovich, Bradley C. ;
Blute, Michael L. ;
Cheville, John C. ;
Kwon, Eugene D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (27) :10391-10396
[9]   B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma [J].
Kryczek, I ;
Zou, L ;
Rodriguez, P ;
Zhu, G ;
Wei, S ;
Mottram, P ;
Brumlik, M ;
Cheng, P ;
Curiel, T ;
Myers, L ;
Lackner, A ;
Alvarez, X ;
Ochoa, A ;
Chen, L ;
Zou, W .
JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (04) :871-881
[10]   B7-DC regulates asthmatic response by an IFN-γ-dependent mechanism [J].
Matsumoto, K ;
Inoue, H ;
Nakano, T ;
Tsuda, M ;
Yoshiura, Y ;
Fukuyama, S ;
Tsushima, F ;
Hoshino, T ;
Aizawa, H ;
Akiba, H ;
Pardoll, D ;
Hara, N ;
Yagita, H ;
Azuma, M ;
Nakanishi, Y .
JOURNAL OF IMMUNOLOGY, 2004, 172 (04) :2530-2541