Armed therapeutic viruses: Strategies and challenges to arming oncolytic viruses with therapeutic genes

被引：123
作者：
Hermiston, TW [1 ]
Kuhn, I [1 ]
机构：
[1] Berlex Biosci, Richmond, CA 94804 USA
来源：
CANCER GENE THERAPY | 2002年 / 9卷 / 12期
关键词：
oncolytic virus; armed therapeutic virus; gene therapy; cancer;
D O I：
10.1038/sj.cgt.7700542
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Oncolytic viruses are attractive therapeutics for cancer because they selectively amplify, through replication and spread, the input dose of virus in the target tumor. To date, clinical trials have demonstrated marked safety but have not realized their theoretical efficacy potential. In this review, we consider the potential of armed therapeutic viruses, whose lytic potential is enhanced by genetically engineered therapeutic transgene expression from the virus, as potential vehicles to increase the potency of these agents. Several classes of therapeutic genes are outlined, and potential synergies and hurdles to their delivery from replicating viruses are discussed.
引用
收藏
页码：1022 / 1035
页数：14
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