Methylene Blue - a therapeutic dye for all seasons?

被引：315

作者：

Wainwright, M ^{[1
]}

Crossley, KB

机构：

[1] Univ Leeds, Dept Colour Chem, Ctr Photodynam Therapy & Photobiol, Leeds LS2 9JT, W Yorkshire, England

[2] Minneapolis VA Med Ctr, Dept Internal Med, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA

来源：

JOURNAL OF CHEMOTHERAPY | 2002年 / 14卷 / 05期

关键词：

anticancer; antimicrobial; blood; DNA; malaria; Methylene Blue; neuroleptic;

D O I：

10.1179/joc.2002.14.5.431

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Since it was first synthesised in 1876, Methylene Blue (MB) has found uses in many different areas of clinical medicine, ranging from dementia to cancer chemotherapy. In addition, MB formed the basis of antimicrobial chemotherapy - particularly in the area of antimalarials - and eventually led to the discovery of the neuroleptic drug families. More recently, the photosensitising potential of MB and its congeners has been recognised, and these are being applied in various antimicrobial fields, especially that of blood disinfection. The range of activities of MB is due to the combination of its simple chemical structure and facility for oxidation-reduction reactions in situ.

引用

页码：431 / 443

页数：13

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