Identification of t(15;17) and a segmental duplication of chromosome 11q23 in a patient with acute myeloblastic leukemia M2

被引：4

作者：

Li, SB ^{[1
]}

Zhang, LJ

Kern, WF

Andrade, D

Forsberg, JE

Bates, FR

Mulvihill, JJ

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK 73104 USA

来源：

CANCER GENETICS AND CYTOGENETICS | 2002年 / 138卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(02)00588-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 32-year-old man was newly diagnosed with acute myelocytic leukemia, classified as acute myeloblastic leukemia with maturation (AML-M2) according to the French-American-British classification system. Conventional chromosome analysis before chemotherapy treatment revealed an abnormal karyotype: a possible segmental duplication of 11q23, plus a translocation between chromosomes 15 and 17 [t(15;17) (q22;q21.1)] in the majority of cells analyzed. Fluorescence in situ hybridization analysis using commercially available probes confirmed the cytogenetic findings. To our knowledge, this is the first report of a combination of t(15;17) and a segmental duplication of 11q23 in a patient with AML-M2. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：149 / 152

页数：4

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