Insecticide-treated nets provide protection against malaria to children in an area of insecticide resistance in Southern Benin

被引：22

作者：

Bradley, John ^{[1
]}

Ogouyemi-Hounto, Aurore ^{[2
]}

Cornelie, Sylvie ^{[3
]}

Fassinou, Jacob ^{[2
]}

de Tove, Yolande Sissinto Savi ^{[2
]}

Adeothy, Adicath Adeola ^{[2
]}

Tokponnon, Filemon T. ^{[4
]}

Makoutode, Patrick ^{[4
]}

Adechoubou, Alioun ^{[4
]}

Legba, Thibaut ^{[4
]}

Houansou, Telesphore ^{[5
]}

Kinde-Gazard, Dorothee ^{[2
]}

Akogbeto, Martin C. ^{[3
]}

Massougbodji, Achille ^{[2
]}

Knox, Tessa Bellamy ^{[5
]}

Donnelly, Martin ^{[6
]}

Kleinschmidt, Immo ^{[1
]}

机构：

[1] London Sch Hyg & Trop Med, MRC Trop Epidemiol Grp, Keppel St, London WC1E 7HT, England

[2] Fac Sci Sante Cotonou, Unite Enseignement & Rech Parasitol Mycol, Cotonou, Benin

[3] Ctr Rech Entomol Cotonou, Inst Reg Dev, Cotonou, Benin

[4] Programme Natl Lutte Paludisme Cotonou, Cotonou, Benin

[5] World Hlth Org, Geneva, Switzerland

[6] Univ Liverpool Liverpool Sch Trop Med, Liverpool, Merseyside, England

来源：

MALARIA JOURNAL | 2017年 / 16卷

基金：

英国医学研究理事会;

关键词：

Malaria; Insecticide; Pyrethroid; Resistance; Nets; VECTOR CONTROL INTERVENTIONS; PYRETHROID RESISTANCE; EQUATORIAL-GUINEA; WESTERN KENYA; BED NETS; TRANSMISSION; MOSQUITOS; ISLAND; IMPLEMENTATION; MORTALITY;

D O I：

10.1186/s12936-017-1873-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Malaria control is heavily reliant on insecticides, especially pyrethroids. Resistance of mosquitoes to insecticides may threaten the effectiveness of insecticide-based vector control and lead to a resurgence of malaria in Africa. Methods: In 21 villages in Southern Benin with high levels of insecticide resistance, the resistance status of local vectors was measured at the same time as the prevalence of malaria infection in resident children. Results: Children who used LLINs had lower levels of malaria infection [odds ratio = 0.76 (95% CI 0.59, 0.98, p = 0.033)]. There was no evidence that the effectiveness of nets was different in high and low resistance locations (p = 0.513). There was no association between village level resistance and village level malaria prevalence (p = 0.999). Conclusions: LLINs continue to offer individual protection against malaria infection in an area of high resistance. Insecticide resistance is not a reason to stop efforts to increase coverage of LLINs in Africa.

引用

页数：5

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