Catalytic asymmetric Mannich-type reactions using a novel chiral iron complex

被引：1

作者：

Yamashita, Y ^{[1
]}

Ueno, M ^{[1
]}

Kuriyama, Y ^{[1
]}

Kobayashi, S ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2002年 / 344卷 / 09期

关键词：

asymmetric catalysis; iron; Lewis acid; Mannich reaction;

D O I：

10.1002/1615-4169(200210)344:9<929::AID-ADSC929>3.0.CO;2-Z

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Catalytic asymmetric Mannich-type reactions using a novel chiral iron complex have been developed. The reactions proceeded smoothly in the presence of a catalyst prepared from iron(II) chloride, a BINOL derivative, and i-Pr2NEt. The desired products were obtained in good yield with good to high enantioselectivity, when 3,3'-I2BINOL was employed as a chiral ligand. A protic additive such as methanol facilitated the reactions effectively.

引用

页码：929 / 931

页数：3

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