Analyzing the Size of Albumin Macromolecules in Aqueous Solutions

被引：2

作者：

Malomuzh, N. P. ^{[1
]}

Khorolskyi, A., V ^{[2
]}

机构：

[1] Odessa II Mechnikov Natl Univ, UA-65000 Odessa, Ukraine

[2] Poltava VG Korolenko Natl Pedag Univ, UA-36000 Poltava, Ukraine

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2021年 / 95卷 / 02期

关键词：

hydrodynamic radius; macromolecules; shear viscosity; solutions; self-diffusion; albumin macromolecules; cell approach; HUMAN SERUM-ALBUMIN;

D O I：

10.1134/S0036024421020199

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Changes in the structure and size of macromolecules of human and bovine serum albumin in aqueous solutions are considered, depending on temperature, concentration, and acid-base equilibrium. It is found that a change in the hydrodynamic radius of the macromolecule is an indicator of the structural phase transformations of globular proteins. Ways of determining the radii of macromolecules from data on the shear viscosity of solutions and the self-diffusion of macromolecules in them are discussed. The hydrodynamic radii of albumin macromolecules found by these means are compared. It is shown that conclusions can be drawn about the nature of bonding between water molecules and protein macromolecules using the obtained data.

引用

页码：303 / 309

页数：7

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