Degradable Polymer Stars Based on Tannic Acid Cores by ATRP

被引：24

作者：

Cuthbert, Julia ^{[1
]}

Yerneni, Saigopalakrishna S. ^{[2
]}

Sun, Mingkang ^{[1
]}

Fu, Travis ^{[1
]}

Matyjaszewski, Krzysztof ^{[1
]}

机构：

[1] Carnegie Mellon Univ, Dept Chem, 4400 Fifth Ave, Pittsburgh, PA 15213 USA

[2] Carnegie Mellon Univ, Dept Biomed Engn, 5000 Forbes Ave, Pittsburgh, PA 15213 USA

来源：

POLYMERS | 2019年 / 11卷 / 05期

关键词：

degradable polymer; tannic acid; ATRP; polymer star; TRANSFER RADICAL POLYMERIZATION;

D O I：

10.3390/polym11050752

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Degradable polymers are crucial in order to reduce plastic environmental pollution and waste accumulation. In this paper, a natural product, tannic acid was modified to be used as a polymer star core. The tannic acid was modified with atom transfer radical polymerization (ATRP) initiators and characterized by H-1 NMR, FT-IR, and XPS. Twenty-five arm polymer stars were prepared by photoinduced ATRP of poly(methyl methacrylate) (PMMA) or poly(oligo(ethylene oxide) methacrylate) (molar mass M-w = 300 g/mol) (P(OEO(300)MA)). The polymer stars were degraded by cleaving the polymer star arms attached to the core by phenolic esters under mild basic conditions. The stars were analyzed before and after degradation by gel permeation chromatography (GPC). Cytotoxicity assays were performed on the P(OEO(300)MA) stars and corresponding degraded polymers, and were found to be nontoxic at the concentrations tested.

引用

页数：11

共 32 条

[1] Microbial degradation of tannins - A current perspective [J].