Intrahepatic hepatitis B virus replication and liver histology in subjects with occult hepatitis B infection

被引：12

作者：

Wong, D. K. -H. ^{[1
,2
]}

Fung, J. ^{[1
,2
]}

Lee, C. -K. ^{[3
]}

Seto, W. -K. ^{[1
]}

Leung, J. ^{[3
]}

Huang, F. -Y. ^{[1
]}

Lin, C. -K. ^{[3
]}

Lai, C. -L. ^{[1
,2
]}

Yuen, M. -F. ^{[1
,2
]}

机构：

[1] Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, State Key Lab Liver Res, Hong Kong, Hong Kong, Peoples R China

[3] Hosp Author, Hong Kong Red Cross Blood Transfus Serv, Hong Kong, Hong Kong, Peoples R China

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2016年 / 22卷 / 03期

关键词：

Covalently closed circular DNA; hepatitis B virus replication; intrahepatic hepatitis B virus DNA; liver histology; occult hepatitis B infection; DNA;

D O I：

10.1016/j.cmi.2015.10.036

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We studied the intrahepatic hepatitis B virus (HBV) replicative status in 40 people with occult hepatitis B infection (OBI) and 40 patients with chronic hepatitis B (CHB). Intrahepatic HBV DNA, covalently closed circular DNA (cccDNA), and pre-genomic RNA (pgRNA) were quantified. Patients with OBI had median necroinflammation and fibrosis scores of 1 and 0, respectively. Intrahepatic total HBV DNA, cccDNA and pgRNA were detectable in 30 (77%), one (3%) and five (13%) of the participants with OBI, respectively. People with OBI had lower median intrahepatic total HBV DNA than the patients with CHB (p < 0.0001). They had nearly normal liver histology and low intrahepatic HBV replication. Clinical Microbiology and Infection (C) 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：290.e1 / 290.e3

页数：3

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