Radiotherapy with rituximab may be better than radiotherapy alone in first-line treatment of early-stage follicular lymphoma: is it time to change the standard strategy?

被引：22

作者：

Janikova, Andrea ^{[1
,2
]}

Bortlicek, Zbynek ^{[3
,4
]}

Campr, Vit ^{[5
,6
]}

Kopalova, Natasa ^{[1
,2
]}

Benesova, Katerina ^{[7
]}

Belada, David ^{[8
]}

Prochazka, Vit ^{[9
]}

Pytlik, Robert ^{[7
]}

Vokurka, Samuel ^{[10
,11
]}

Pirnos, Jan ^{[12
]}

Duras, Juraj ^{[13
]}

Mocikova, Heidi ^{[14
]}

Mayer, Jiri ^{[1
,2
]}

Trneny, Marek ^{[7
]}

机构：

[1] Masaryk Univ, Dept Internal Med Hematol & Oncol, Jihlavska 20, Brno 62500, Czech Republic

[2] Univ Hosp Brno, Brno 62500, Czech Republic

[3] Masaryk Univ, Fac Med, Inst Biostat & Anal, Brno 62500, Czech Republic

[4] Masaryk Univ, Fac Sci, Brno 62500, Czech Republic

[5] Charles Univ Prague, Fac Med 2, Dept Pathol & Mol Med, Prague, Czech Republic

[6] Fac Hosp Motol, Prague, Czech Republic

[7] Charles Univ Prague, Gen Hosp, Dept Med 1, Prague, Czech Republic

[8] Univ Hosp Hradec Kralove, Dept Clin Hematol, Hradec Kralove, Czech Republic

[9] Univ Hosp Olomouc, Dept Hematol, Olomouc, Czech Republic

[10] Charles Univ Prague, Dept Hematooncol, Plzen, Czech Republic

[11] Univ Hosp Plzen, Plzen, Czech Republic

[12] Hosp Ceske Budejovice, Dept Oncol, Ceske Budejovice, Czech Republic

[13] Teaching Hosp Ostrava, Dept Clin Hematol, Ostrava, Czech Republic

[14] Univ Hosp Kralovske Vinohrady, Dept Hematol, Prague, Czech Republic

来源：

LEUKEMIA & LYMPHOMA | 2015年 / 56卷 / 08期

关键词：

Follicular lymphoma; rituximab; radiotherapy; NON-HODGKINS-LYMPHOMA; TERM-FOLLOW-UP; POSITRON-EMISSION-TOMOGRAPHY; INVOLVED FIELD RADIOTHERAPY; LOW-GRADE; RADIATION-THERAPY; CELLS; MANAGEMENT; TRANSLOCATION; SURVIVAL;

D O I：

10.3109/10428194.2014.990010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Early-stage follicular lymphoma (FL) has traditionally been treated with involved-field radiotherapy (RT). Rituximab (R) is a low-toxic, efficient systemic therapy for FL, but there are no data about its clinical impact in early FL. We retrospectively analyzed 93 patients with stage I-II indolent FL treated with RT (n = 65) or RT + R (n = 14) or R alone (n = 14). Median follow-up was 5.0 years for patients with RT, 2.8 years for the RT + R subgroup and 2.5 years for patients treated with R. The complete response rate was 92%, 100% and 86% (not significant) and the median PFS was 3.3 years, not reached and 4.9 years (p = 0.035) for the RT, RT + R and R arms, with no impact on overall survival. R combined with RT seems to give better results in terms of global FL control, but longer follow-up and prospective comparison are needed to verify these results.

引用

页码：2350 / 2356

页数：7

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