At the Heart of Immune checkpoint Inhibitor-Induced Immune Toxicity

被引：2
作者：
Young, Arabella [1 ,2 ,3 ]
Bluestone, Jeffrey A. [1 ,2 ,4 ]
机构：
[1] Univ Calif San Francisco, Sean N Parker Autoimmune Res Lab, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA
[3] QIMR Berghofer Med Res Inst, Herston, Qld, Australia
[4] Sonoma Biotherapeut, San Francisco, CA USA
来源：
CANCER DISCOVERY | 2021年 / 11卷 / 03期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
D O I：
10.1158/2159-8290.CD-21-0091
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Wei and colleagues showcase a genetic mouse model of immune-mediated myocarditis that shares homology with immune checkpoint inhibitor (CPI)-induced myocarditis in patients with cancer. They demonstrate that abatacept (CTLA4-Ig) limits cardiac toxicity in the mouse model and, thus, may ameliorate the CPI-induced myocarditis in patients with cancer while potentially maintaining antitumor activity.
引用
收藏
页码：537 / 539
页数：3
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