At the Heart of Immune checkpoint Inhibitor-Induced Immune Toxicity

被引：2

作者：

Young, Arabella ^{[1
,2
,3
]}

Bluestone, Jeffrey A. ^{[1
,2
,4
]}

机构：

[1] Univ Calif San Francisco, Sean N Parker Autoimmune Res Lab, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Ctr Diabet, San Francisco, CA 94143 USA

[3] QIMR Berghofer Med Res Inst, Herston, Qld, Australia

[4] Sonoma Biotherapeut, San Francisco, CA USA

来源：

CANCER DISCOVERY | 2021年 / 11卷 / 03期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

D O I：

10.1158/2159-8290.CD-21-0091

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Wei and colleagues showcase a genetic mouse model of immune-mediated myocarditis that shares homology with immune checkpoint inhibitor (CPI)-induced myocarditis in patients with cancer. They demonstrate that abatacept (CTLA4-Ig) limits cardiac toxicity in the mouse model and, thus, may ameliorate the CPI-induced myocarditis in patients with cancer while potentially maintaining antitumor activity.

引用

页码：537 / 539

页数：3

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