The present review examines (a) the published literature on the association between marital quality and depression in mixed-age groups, and (b) the association between these variables during later life. With regards to both issues, target studies were grouped into three categories: cross-sectional research, longitudinal research, and research on mediator and moderator variables. The main theoretical models that account for the relation between marital quality and depression are briefly presented. Whereas the evidence for a cross-sectional association between marital quality and depression seems robust, longitudinal research as well as research on mediator/moderator variables is less conclusive. This is particularly so vis-a-vis older adults, where studies are scarce. We conclude with suggestions for future research and the clinical implications of work in this area.