Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis

被引：311

作者：

Moretta, A ^{[1
]}

Biassoni, R

Bottino, C

Mingari, MC

Moretta, L

机构：

[1] Univ Genoa, Dipartimento Med Sperimentale, Genoa, Italy

[2] Ist Nazl Ric Canc, I-16132 Genoa, Italy

[3] Univ Genoa, Dipartimento Oncol Biol & Genet, Genoa, Italy

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 05期

关键词：

D O I：

10.1016/S0167-5699(00)01596-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells can detect whether cells have undergone tumor transformation or viral infection. The discovery of specific inhibitory receptors for major histocompatibility complex class I molecules clarified the basis of this discrimination. However, the receptors responsible for NK-cell triggering in the process of natural cytotoxicity remained elusive until recently. Here, Alessandro Moretta and colleagues describe the identification and characterization of several such receptors.

引用

页码：228 / 234

页数：7

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