Increased homocysteine in heart failure: a result of renal impairment?

被引：8

作者：

Aksoy, Nur ^{[1
]}

Aksoy, Mehmet

Cakmak, Mahmut

Gergerlioglu, Hasan Serdar

Davutoglu, Vedat

Soydinc, Serdar

Meram, Iclal

机构：

[1] Gaziantep Univ, Vocat Sch Higher Educ, Hlth Serv, TR-27310 Gaziantep, Turkey

[2] Gaziantep Univ, Sch Med, Dept Cardiol, TR-27310 Gaziantep, Turkey

[3] Siyami Ersek Thorac & Cardiovasc Surg Ctr, Dept Cardiol, Istanbul, Turkey

[4] Gaziantep Univ, Sch Med, Dept Physiol, TR-27310 Gaziantep, Turkey

[5] Gaziantep Univ, Sch Med, Dept Biochem, TR-27310 Gaziantep, Turkey

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2006年 / 44卷 / 11期

关键词：

heart failure; hyperhomocysteinemia; renal function;

D O I：

10.1515/CCLM.2006.245

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: Hyperhomocysteinemia may constitute a risk factor for patients with severe heart failure. This study examines the relationship between plasma homocysteine concentration and left ventricular ejection fraction with renal function in heart failure patients free of coronary artery disease. Methods: Left ventricular ejection fraction was documented in 62 patients with advanced heart failure who had no proven significant coronary artery stenosis. Glomerular filtration rate was measured using the Cockroft-Gault equation. Results: Elevated homocysteine levels (>= 15 mu mol/L) were detected in 22 patients. Low glomerular filtration rate was observed in patients who had normal serum creatinine concentration. Homocysteine was strongly correlated with age, duration of disease, left ventricular ejection fraction, serum creatinine, and glomerular filtration rate. Statistically significant trends were observed across respective homocysteine quartiles. However, by multivariate regression, the strongest predictor of homocysteine was the glomerular filtration rate. Conclusions: Impaired renal function leads to a diminished clearance rate, which can be a prominent pathophysiological mechanism in the elevation of homocysteine concentration in heart failure.

引用

页码：1324 / 1329

页数：6

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