The role of NOS3 in stem cell mobilization

被引：54

作者：

Aicher, A ^{[1
]}

Heeschen, C ^{[1
]}

Dimmeler, S ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Dept Internal Med 4, D-60590 Frankfurt, Germany

来源：

TRENDS IN MOLECULAR MEDICINE | 2004年 / 10卷 / 09期

关键词：

D O I：

10.1016/j.molmed.2004.07.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In response to injury, stem cells are mobilized from the bone marrow into the circulation and home to sites of ischemia, where they contribute to the formation of new blood vessels. This mobilization is mediated by proteinases. Matrix metalloproteinase-9 (MMP-9) is essential for the mobilization that is induced by growth factors (such as vascular endothelial growth factor, VEGF) and cytokines (such as stromal-cell-derived factor-1). The mechanism by which MMP-9 and VEGF interact to promote stem cell mobilization is gradually being unraveled. Here, the activation of NOS3 (endothelial nitric oxide synthase) in the bone marrow microenvironment is emphasized as one such mechanistic link and a potential therapeutic target for patients with chronic cardiovascular disease.

引用

页码：421 / 425

页数：5

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