Effects of salicylate on transient outward and delayed rectifier potassium channels in rat inferior colliculus neurons

被引：22
作者：
Liu, YX [1 ]
Li, XP [1 ]
机构：
[1] Peking Univ, 3rd Hosp, Dept Otorhinolaryngol, Beijing 100083, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2004年 / 369卷 / 02期
基金：
中国国家自然科学基金;
关键词：
salicylate; tinnitus; inferior colliculus; potassium current; patch clamp;
D O I：
10.1016/j.neulet.2004.07.037
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects of salicylate (a tinnitus inducer) were studied on the transient outward potassium current (I-K(A)) and the delayed rectifier potassium current (I-K(DR)) in acutely dissociated rat inferior colliculus neurons by the whole-cell voltage-clamp method. Salicylate's inhibition of the amplitude Of I-K(A) and I-K(DR) was concentration-dependent. The IC50 values for the blocking action of salicylate on I-K(A) and I-K(DR) were 2.27 and 0.80 mM, respectively. At a concentration of I mM, salicylate significantly shifted the activation and inactivation Curves Of I-K(DR) negatively by approximately 11 and 24 mV, respectively, but did not shift the I-K(A) curves. In conclusion, salicylate inhibits both I-K(A) and IK(DR) in rat inferior colliculus neurons but only significantly affects the activation and inactivation kinetics Of I-K(DR). Depression Of I-K(DR) by salicylate may play an important role in salicylate-induced tinnitus. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：115 / 120
页数：6
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