Toxicogenomic Effects in Rat Blood Leukocytes and Chemoprophylaxis of Radiation-Induced Carcinogenesis

被引：2
|
作者：
Ivanov, S. D. [1 ]
Bespalov, V. G. [1 ]
Semenov, A. L. [1 ]
Kovan'ko, E. G. [1 ]
Aleksandrov, V. A. [2 ]
机构：
[1] Minist Hlth Russian Federat, Russian Res Ctr Radiol & Surg Technol, St Petersburg, Russia
[2] Minist Hlth Russian Federat, NN Petrov Res Inst Oncol, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 160卷 / 05期
关键词：
rats; radiation-induced carcinogenesis; toxicogenomic effects; chemoprophylaxis; DIFLUOROMETHYLORNITHINE; CHEMOPREVENTION; CANCER;
D O I：
10.1007/s10517-016-3255-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Toxicogenomic parameters were studied in the blood of female rats after exposure to ionizing gamma-radiation in a dose of 4 Gy and chemoprophylaxis with alpha-difluoromethylornithine, eleutherococcus or leuzea extracts, which were used in animals with morphological manifestations of tumor growth under conditions of radiation-induced carcinogenesis. Life-time evaluation of toxicogenomic effects was carried out by express method for measurements of blood nucleotid DNA - fluorescent indication. The level of hyperaneu/polyploidy increased in the blood leukocytes of control rats 30 days after radiation exposure. A significant decrease of genotoxicity as a result of drug treatment in comparison with the number and multiplicity of tumors in irradiated animals was found only in the endocrine and reproductive organs of rats treated by eleutherococcus extract.
引用
收藏
页码：705 / 708
页数：4
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