Interleukin-3 Prevents Cellular Death Induced by Oxidative Stress in HEK293 Cells

被引：3

作者：

Lopez, Camila ^{[1
]}

Zamorano, Patricia ^{[1
]}

Teuber, Stefanie ^{[1
]}

Salas, Monica ^{[1
]}

Otth, Carola ^{[2
,3
]}

Hidalgo, Maria A. ^{[4
]}

Concha, Ilona ^{[1
]}

Zambrano, Angara ^{[1
,3
]}

机构：

[1] Inst Bioquim & Microbiol, Fac Ciencias, Valdivia, Chile

[2] Inst Microbiol Clin, Fac Med, Valdivia, Los Rios, Chile

[3] Univ Austral Chile, Ctr Interdisciplinary Studies Nervous Syst CISNe, Valdivia, Chile

[4] Univ Austral Chile, Fac Ciencias Vet, Inst Farmacol, Valdivia, Los Rios, Chile

来源：

JOURNAL OF CELLULAR BIOCHEMISTRY | 2017年 / 118卷 / 06期

关键词：

IL-3; CELL SURVIVAL; PI3k/Akt; Erk; OXIDATIVE STRESS; COLONY-STIMULATING FACTOR; MALE GERM-CELLS; GM-CSF; INCREASED GLUCOSE; NEURONAL DEATH; GROWTH-FACTORS; IL-3; ACTIVATION; SURVIVAL; JAK2;

D O I：

10.1002/jcb.25790

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-3 (IL-3) is a well-characterized growth factor in hematopoietic cells, but it is also expressed in other cell types with poorly described functions. Many studies have provided evidence that IL-3 plays an important role in cell survival. We have previously shown that IL-3 is able to increase glucose uptake in HEK293 cells, suggesting that this factor requires sustained glucose metabolism to promote cell survival. In this study, we demonstrate that IL-3 contributes to cell survival under oxidative stress, a prominent feature in the pathophysiology of cancer, diabetes, and neurodegenerative diseases, as well as in the aging process. Our results suggest a molecular mechanism that involves signaling pathways mediated by PI-3k/Akt and Erk. Altogether, these findings show an important role for IL-3 in supporting the viability of non-hematopoietic systems. J. Cell. Biochem. 118: 1330-1340, 2017. (C) 2016 Wiley Periodicals, Inc.

引用

页码：1330 / 1340

页数：11

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