NRAMP1 and TNF-α polymorphisms and susceptibility to tuberculosis in Thais

被引：53
作者：
Vejbaesya, Sasijit
Chierakul, Nitipatana
Luangtrakool, Panpimon
Sermduangprateep, Chutima
机构：
[1] Mahidol Univ, Fac Med, Siriraj Hosp, Dept Transfus Med, Bangkok 10700, Thailand
[2] Mahidol Univ, Fac Med, Siriraj Hosp, Dept Med, Bangkok 10700, Thailand
来源：
RESPIROLOGY | 2007年 / 12卷 / 02期
关键词：
natural resistance-associated macrophage protein gene 1; Thais; tuberculosis; tumour necrosis factor;
D O I：
10.1111/j.1440-1843.2006.01037.x
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Polymorphisms in the natural resistance-associated macrophage protein gene 1 (NRAMP1) and tumour necrosis factor (TNF)-alpha gene have been found to be associated with susceptibility to tuberculosis in different populations. However, the results are inconsistent. This study aimed to determine whether NRAMP1 and TNF-alpha variants are associated with tuberculosis in Thais. Polymorphisms of NRAMP1 at INT4, D543N and the 3' untranslated region, and of TNF-alpha at +488, -238, and -308, were examined in 149 tuberculosis patients and 147 healthy controls. PCR using sequence-specific oligonucleotides and sequence-specific priming were used to genotype the NRAMP1 and TNF polymorphisms, respectively. There were no significant differences in the distribution of the genotype frequencies for the NRAMP1 and TNF-alpha polymorphisms between the patients and controls. The NRAMP1 and TNF-alpha genes are not associated with susceptibility to tuberculosis in Thais.
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收藏
页码：202 / 206
页数：5
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