Multifunctional TaCu-nanotubes coated titanium for enhanced bacteriostatic, angiogenic and osteogenic properties

被引：26
作者：
Wu, Shuyi [1 ]
Shen, Xinkun [1 ]
Chen, Mengyu [1 ]
Yie, K. Hii Ru [1 ]
Zhou, Zixin [1 ]
Al-Baadani, Mohammed A. [1 ]
Fang, Kai [1 ]
Al-Bishari, Abdullrahman M. [1 ]
Deng, Zhennan [1 ]
Liu, Jinsong [1 ]
Yao, Lili [1 ]
机构：
[1] Wenzhou Med Univ, Sch & Hosp Stomatol, Wenzhou 325027, Peoples R China
来源：
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2021年 / 120卷
基金：
中国国家自然科学基金;
关键词：
Bacteriostasis; Angiogenesis; Osteogenesis; Tantalum copper composite nanotubes;
D O I：
10.1016/j.msec.2020.111777
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
In this study, multifunctional tantalum copper composite nanotubes (TaCu-NTs) were coated on titanium for enhanced bacteriostatic, angiogenic and osteogenic properties. Three coatings of Ta, TaCu1 (Ta: Cu = 4:1 at.%), and TaCu2 (Ta: Cu = 1:1 at.%) were deposited on titanium by magnetron sputtering. The bare titanium and the three coatings were subsequently anodized into four kinds of nanotubes (NT) of TNT, Ta-NT, TaCu1-NT, and TaCu2-NT, respectively. The released copper ions measured by inductively coupled plasma atomic emission spectroscopy (ICP/AES) presented that TaCu2-NT coating released the highest amount of copper ions, which led to the best bacteriostasis against Escherichia coli and Staphylococcus aureus. Potentiodynamic polarization tests clarified that Ta-NT showed the highest corrosion resistance, followed by TaCu1-NT and TaCu2-NT. TaCu2-NT showed not only the best angiogenic property in terms of cell migration, tube formation, and real-time quantitative polymerase chain reaction (RT-qPCR) of human umbilical vein endothelial cells (HUVECs), but also the best osteogenic property in terms of cell viability, alkaline phosphatase activity, and mineralization of MC3T3-E1 cells. Therefore, TaCu2-NT coating has a greater potential than the other coatings of TNT, Ta-NT and TaCu1-NT in promoting bacteriostasis, angiogenesis and osteointegration for titanium implants.
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页数：13
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