TOXICOKINETICS OF PERFLUOROOCTANE SULFONATE IN RAINBOW TROUT (ONCORHYNCHUS MYKISS)

被引:30
|
作者
Consoer, Daniel M. [1 ,2 ]
Hoffman, Alex D. [1 ]
Fitzsimmons, Patrick N. [1 ]
Kosian, Patricia A. [1 ]
Nichols, John W. [1 ]
机构
[1] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Mid Continent Ecol Div, Duluth, MN USA
[2] Univ Minnesota, Dept Toxicol, Duluth, MN 55812 USA
关键词
Perfluorooctane sulfonate; Toxicokinetics; Renal elimination; Tissue distribution; Bioaccumulation; CHAIN PERFLUORINATED ACIDS; ORGANIC ANION TRANSPORTER; TANDEM MASS-SPECTROMETRY; HUMAN SERUM-ALBUMIN; TISSUE DISTRIBUTION; PERFLUOROALKYL ACIDS; P-GLYCOPROTEIN; EFFLUX TRANSPORTERS; AQUATIC ORGANISMS; WINTER FLOUNDER;
D O I
10.1002/etc.3230
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Rainbow trout (Oncorhynchus mykiss) confined to respirometer-metabolism chambers were dosed with perfluorooctane sulfonate (PFOS) by intra-arterial injection and sampled to obtain concentration time-course data for plasma and either urine or expired water. The data were then analyzed using a 2-compartment clearance-volume model. Renal and branchial clearance rates (mL/d/kg) determined for all experiments averaged 19% and 81% of total clearance, respectively. Expressed as mean values for all experiments, the steady-state volume of distribution was 277mL/kg and the terminal half-life was 86.8 d. Additional animals were exposed to PFOS in water, resulting in an average calculated branchial uptake efficiency of 0.36%. The renal clearance rate determined in the present study is approximately 75 times lower than that determined in earlier studies with perfluorooctanoate (PFOA). Previously, it was suggested that PFOA is a substrate for membrane transporters in the trout kidney. The present study suggests that glomerular filtration may be sufficient to explain the observed renal clearance rate for PFOS, although a role for membrane transporters cannot be ruled out. These findings demonstrate that models developed to predict the bioaccumulation of perfluoroalkyl acids by fish must account for differences in renal clearance of individual compounds. (c) 2015 SETAC
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页码:717 / 727
页数:11
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