Clinical characteristics of sarcoidosis patients with systemic sclerosis-specific autoantibody: Possible involvement of thymus and activation-regulated chemokine and a review of the published works

被引:6
作者
Ueda-Hayakawa, Ikuko [1 ]
Chuyen Thi Hong Nguyen [1 ,2 ]
Kishimoto, Izumi [1 ]
Nhung Thi My Ly [1 ]
Okamoto, Hiroyuki [1 ]
机构
[1] Kansai Med Univ, Dept Dermatol, 2-5-1 Shin Machi, Hirakata, Osaka 5731010, Japan
[2] Univ Med & Pharm, Dept Dermatol & Venereol, Ho Chi Minh City, Vietnam
关键词
anticentromere antibody; autoantibody; sarcoidosis; systemic sclerosis; thymus and activation-regulated chemokine; SOLUBLE INTERLEUKIN-2 RECEPTORS; SERUM-LEVELS; DISEASE; CLASSIFICATION; LEVEL; TARC;
D O I
10.1111/1346-8138.14932
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Sarcoidosis and systemic sclerosis (SSc) are both multisystem disorders of unknown etiology. Some cases having both sarcoidosis and SSc have been reported previously. The present study was to investigate clinical features in sarcoidosis patients who possessed SSc-specific autoantibody. The pathophysiology of each disease, including shared pathways leading to the development of both conditions, is reviewed in addition to previous reports of patients with concomitant SSc and sarcoidosis. SSc-specific autoantibodies including anticentromere antibody (ACA), anti-topoisomerase I antibody, anti-RNA polymerase III antibody and anti-U1RNP antibody were examined in sarcoidosis patients. Complete medical histories, clinical examinations and laboratory tests were conducted for all patients. For reviewing previously published reports, all cases were retrieved through a PubMed search. ACA was most frequently observed in sarcoidosis patients. Plaques and papules were the most frequent as the cutaneous sarcoidosis lesions. Soluble interleukin-2 receptor was elevated in most of the cases (6/ 8, 75%), and thymus and activation-regulated chemokine (TARC) was elevated in all cases (6/ 6, 100%). Together with our two cases (cases 1 and 3), a review of previously reported cases of sarcoidosis patients concomitant with SSc showed high frequency of ACA and plaques as cutaneous lesions. We suppose that TARC may play some roles in the production of SSc-specific autoantibodies and development of concomitance with SSc in sarcoidosis, although the mechanisms remain unknown.
引用
收藏
页码:577 / 583
页数:7
相关论文
共 53 条
[1]   New pathogenetic insights into the sarcoid granuloma [J].
Agostini, C ;
Adami, F ;
Semenzato, G .
CURRENT OPINION IN RHEUMATOLOGY, 2000, 12 (01) :71-76
[2]  
Atamas SP, 1999, ARTHRITIS RHEUM, V42, P1168, DOI 10.1002/1529-0131(199906)42:6<1168::AID-ANR13>3.0.CO
[3]  
2-L
[4]  
Borges da Costa Joao, 2009, Dermatol Online J, V15, P11
[5]  
COX D, 1995, J RHEUMATOL, V22, P881
[6]  
DeBandt M, 1997, BRIT J RHEUMATOL, V36, P117
[7]   Sarcoidosis [J].
English, JC ;
Patel, PJ ;
Greer, KE .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2001, 44 (05) :725-743
[8]   SARCOIDOSIS IN AUTOIMMUNE-DISEASE [J].
ENZENAUER, RJ ;
WEST, SG .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 1992, 22 (01) :1-17
[9]   Serum levels of a Th1 chemoattractant IP-10 and Th2 chemoattractants, TARC and MDC, are elevated in patients with systemic sclerosis [J].
Fujii, H ;
Shimada, Y ;
Hasegawa, M ;
Takehara, K ;
Sato, S .
JOURNAL OF DERMATOLOGICAL SCIENCE, 2004, 35 (01) :43-51
[10]   Rational therapy in the treatment of systemic sclerosis [J].
Furst, DE .
CURRENT OPINION IN RHEUMATOLOGY, 2000, 12 (06) :540-544