RNA metabolism in neurodegenerative disease

被引：102

作者：

Liu, Elaine Y. ^{[1
]}

Cali, Christopher P. ^{[1
]}

Lee, Edward B. ^{[1
]}

机构：

[1] Univ Penn, Perelman Sch Med, Translat Neuropathol Res Labs, 613A Stellar Chance Labs, Philadelphia, PA 19104 USA

来源：

DISEASE MODELS & MECHANISMS | 2017年 / 10卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Disease; RNA binding proteins; Microsatellite repeats; miRNA; tRNA; lncRNA; RNA; AMYOTROPHIC-LATERAL-SCLEROSIS; DNA-BINDING PROTEIN; FRONTOTEMPORAL LOBAR DEGENERATION; AMYLOID PRECURSOR PROTEIN; LOSS-OF-FUNCTION; ALZHEIMERS-DISEASE; MYOTONIC-DYSTROPHY; NONCODING RNA; HEXANUCLEOTIDE REPEAT; HUNTINGTONS-DISEASE;

D O I：

10.1242/dmm.028613

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging-related neurodegenerative diseases are progressive and fatal neurological diseases that are characterized by irreversible neuron loss and gliosis. With a growing population of aging individuals, there is a pressing need to better understand the basic biology underlying these diseases. Although diverse disease mechanisms have been implicated in neurodegeneration, a common theme of altered RNA processing has emerged as a unifying contributing factor to neurodegenerative disease. RNA processing includes a series of distinct processes, including RNA splicing, transport and stability, as well as the biogenesis of non-coding RNAs. Here, we highlight how some of these mechanisms are altered in neurodegenerative disease, including the mislocalization of RNA-binding proteins and their sequestration induced by microsatellite repeats, microRNA biogenesis alterations and defective tRNA biogenesis, as well as changes to long-intergenic non-coding RNAs. We also highlight potential therapeutic interventions for each of these mechanisms.

引用

页码：508 / 517

页数：10

共 177 条

[71] MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington's Disease-Related Mechanisms [J].

Jovicic, Ana ;

Jolissaint, Julien Francisco Zaldivar ;

Moser, Roger ;

Santos, Mariana de Fatima Silva ;

Luthi-Carter, Ruth .

PLOS ONE, 2013, 8 (01)

[72] TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis [J].

Kabashi, Edor ;

Valdmanis, Paul N. ;

Dion, Patrick ;

Spiegelman, Dan ;

McConkey, Brendan J. ;

Velde, Christine Vande ;

Bouchard, Jean-Pierre ;

Lacomblez, Lucette ;

Pochigaeva, Ksenia ;

Salachas, Francois ;

Pradat, Pierre-Francois ;

Camu, William ;

Meininger, Vincent ;

Dupre, Nicolas ;

Rouleau, Guy A. .

NATURE GENETICS, 2008, 40 (05) :572-574

[73] Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function [J].

Karaca, Ender ;

Weitzer, Stefan ;

Pehlivan, Davut ;

Shiraishi, Hiroshi ;

Gogakos, Tasos ;

Hanada, Toshikatsu ;

Jhangiani, Shalini N. ;

Wiszniewski, Wojciech ;

Withers, Marjorie ;

Campbell, Ian M. ;

Erdin, Serkan ;

Isikay, Sedat ;

Franco, Luis M. ;

Gonzaga-Jauregui, Claudia ;

Gambin, Tomasz ;

Gelowani, Violet ;

Hunter, Jill V. ;

Yesil, Gozde ;

Koparir, Erkan ;

Yilmaz, Sarenur ;

Brown, Miguel ;

Briskin, Daniel ;

Hafner, Markus ;

Morozov, Pavel ;

Farazi, Thalia A. ;

Bernreuther, Christian ;

Glatzel, Markus ;

Trattnig, Siegfried ;

Friske, Joachim ;

Kronnerwetter, Claudia ;

Bainbridge, Matthew N. ;

Gezdirici, Alper ;

Seven, Mehmet ;

Muzny, Donna M. ;

Boerwinkle, Eric ;

Ozen, Mustafa ;

Clausen, Tim ;

Tuschl, Thomas ;

Yuksel, Adnan ;

Hess, Andreas ;

Gibbs, Richard A. ;

Martinez, Javier ;

Penninger, Josef M. ;

Lupski, James R. .

CELL, 2014, 157 (03) :636-650

[74] Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels [J].

Kato, Masato ;

Han, Tina W. ;

Xie, Shanhai ;

Shi, Kevin ;

Du, Xinlin ;

Wu, Leeju C. ;

Mirzaei, Hamid ;

Goldsmith, Elizabeth J. ;

Longgood, Jamie ;

Pei, Jimin ;

Grishin, Nick V. ;

Frantz, Douglas E. ;

Schneider, Jay W. ;

Chen, She ;

Li, Lin ;

Sawaya, Michael R. ;

Eisenberg, David ;

Tycko, Robert ;

McKnight, Steven L. .

CELL, 2012, 149 (04) :753-767

[75] TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes [J].

Kawahara, Yukio ;

Mieda-Sato, Ai .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (09) :3347-3352

[76] Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression [J].

Khalil, Ahmad M. ;

Guttman, Mitchell ;

Huarte, Maite ;

Garber, Manuel ;

Raj, Arjun ;

Morales, Dianali Rivea ;

Thomas, Kelly ;

Presser, Aviva ;

Bernstein, Bradley E. ;

van Oudenaarden, Alexander ;

Regev, Aviv ;

Lander, Eric S. ;

Rinn, John L. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (28) :11667-11672

[77] Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS [J].

Kim, Hong Joo ;

Kim, Nam Chul ;

Wang, Yong-Dong ;

Scarborough, Emily A. ;

Moore, Jennifer ;

Diaz, Zamia ;

MacLea, Kyle S. ;

Freibaum, Brian ;

Li, Songqing ;

Molliex, Amandine ;

Kanagaraj, Anderson P. ;

Carter, Robert ;

Boylan, Kevin B. ;

Wojtas, Aleksandra M. ;

Rademakers, Rosa ;

Pinkus, Jack L. ;

Greenberg, Steven A. ;

Trojanowski, John Q. ;

Traynor, Bryan J. ;

Smith, Bradley N. ;

Topp, Simon ;

Gkazi, Athina-Soragia ;

Miller, Jack ;

Shaw, Christopher E. ;

Kottlors, Michael ;

Kirschner, Janbernd ;

Pestronk, Alan ;

Li, Yun R. ;

Ford, Alice Flynn ;

Gitler, Aaron D. ;

Benatar, Michael ;

King, Oliver D. ;

Kimonis, Virginia E. ;

Ross, Eric D. ;

Weihl, Conrad C. ;

Shorter, James ;

Taylor, J. Paul .

NATURE, 2013, 495 (7442) :467-+

[78] A microRNA feedback circuit in midbrain dopamine neurons [J].

Kim, Jongpil ;

Inoue, Keiichi ;

Ishii, Jennifer ;

Vanti, William B. ;

Voronov, Sergey V. ;

Murchison, Elizabeth ;

Hannon, Gregory ;

Abeliovich, Asa .

SCIENCE, 2007, 317 (5842) :1220-1224

[79] miR-126 contributes to Parkinson's disease by dysregulating the insulin-like growth factor/phosphoinositide 3-kinase signaling [J].

Kim, Woori ;

Lee, Yenarae ;

McKenna, Noah D. ;

Yi, Ming ;

Simunovic, Filip ;

Wang, Yulei ;

Kong, Benjamin ;

Rooney, Robert J. ;

Seo, Hyemyung ;

Stephens, Robert M. ;

Sonntag, Kai C. .

NEUROBIOLOGY OF AGING, 2014, 35 (07) :1712-1721

[80] An mRNA m7G cap binding-like motif within human Ago2 represses translation [J].

Kiriakidou, Marianthi ;

Tan, Grace S. ;

Lamprinaki, Styliani ;

De Planell-Saguer, Mariangels ;

Nelson, Peter T. ;

Mourelatos, Zissimos .

CELL, 2007, 129 (06) :1141-1151

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