Gut microbiota: Implications in Parkinson's disease

被引：170
作者：
Parashar, Arun [1 ]
Udayabanu, Malairaman [1 ]
机构：
[1] Jaypee Univ Informat Technol, PO Waknaghat, Waknaghat 173234, Himachal Prades, India
来源：
PARKINSONISM & RELATED DISORDERS | 2017年 / 38卷
关键词：
Gut microbiota; Parkinson's disease; Probiotics; Germ-free; Antibiotics; Fecal transplant; INTESTINAL BACTERIAL OVERGROWTH; L-DOPA ABSORPTION; ALPHA-SYNUCLEIN; DIETARY-INTAKE; VITAMIN-E; HELICOBACTER; MODEL; BRAIN; RISK; INFLAMMATION;
D O I：
10.1016/j.parkreldis.2017.02.002
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Gut microbiota (GM) can influence various neurological outcomes, like cognition, learning, and memory. Commensal GM modulates brain development and behavior and has been implicated in several neurological disorders like Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, anxiety, stress and much more. A recent study has shown that Parkinson's disease patients suffer from GM dysbiosis, but whether it is a cause or an effect is yet to be understood. In this review, we try to connect the dots between GM and PD pathology using direct and indirect evidence. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1 / 7
页数：7
相关论文
共 108 条
[81]   Folate production by bifidobacteria as a potential probiotic property [J].
Pompei, Anna ;
Cordisco, Lisa ;
Amaretti, Alberto ;
Zanoni, Simona ;
Matteuzzi, Diego ;
Rossi, Maddalena .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2007, 73 (01) :179-185
[82]   Minocycline Protects Dopaminergic Neurons Against Long-Term Rotenone Toxicity [J].
Radad, Khaled ;
Moldzio, Rudolf ;
Rausch, Wolf-Dieter .
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 2010, 37 (01) :81-85
[83]  
Ravina B, 2006, NEUROLOGY, V66, P664
[84]   Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease [J].
Sampson, Timothy R. ;
Debelius, Justine W. ;
Thron, Taren ;
Janssen, Stefan ;
Shastri, Gauri G. ;
Ilhan, Zehra Esra ;
Challis, Collin ;
Schretter, Catherine E. ;
Rocha, Sandra ;
Gradinaru, Viviana ;
Chesselet, Marie-Francoise ;
Keshavarzian, Ali ;
Shannon, Kathleen M. ;
Krajmalnik-Brown, Rosa ;
Wittung-Stafshede, Pernilla ;
Knight, Rob ;
Mazmanian, Sarkis K. .
CELL, 2016, 167 (06) :1469-+
[85]   Medical records documentation of constipation preceding Parkinson disease A case-control study [J].
Savica, R. ;
Carlin, J. M. ;
Grossardt, B. R. ;
Bower, J. H. ;
Ahlskog, J. E. ;
Maraganore, D. M. ;
Bharucha, A. E. ;
Rocca, W. A. .
NEUROLOGY, 2009, 73 (21) :1752-1758
[86]   Linking Smoking, Coffee, Urate, and Parkinson's Disease - A Role for Gut Microbiota? [J].
Scheperjans, Filip ;
Pekkonen, Eero ;
Kaakkola, Seppo ;
Auvinen, Petri .
JOURNAL OF PARKINSONS DISEASE, 2015, 5 (02) :255-262
[87]   Gut Microbiota Are Related to Parkinson's Disease and Clinical Phenotype [J].
Scheperjans, Filip ;
Aho, Velma ;
Pereira, Pedro A. B. ;
Koskinen, Kaisa ;
Paulin, Lars ;
Pekkonen, Eero ;
Haapaniemi, Elena ;
Kaakkola, Seppo ;
Eerola-Rautio, Johanna ;
Pohja, Marjatta ;
Kinnunen, Esko ;
Murros, Kari ;
Auvinen, Petri .
MOVEMENT DISORDERS, 2015, 30 (03) :350-358
[88]   Helicobacter pylori AlpA and AlpB Bind Host Laminin and Influence Gastric Inflammation in Gerbils [J].
Senkovich, Olga A. ;
Yin, Jun ;
Ekshyyan, Viktoriya ;
Conant, Carolyn ;
Traylor, James ;
Adegboyega, Patrick ;
McGee, David J. ;
Rhoads, Robert E. ;
Slepenkov, Sergey ;
Testerman, Traci L. .
INFECTION AND IMMUNITY, 2011, 79 (08) :3106-3116
[89]   Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases [J].
Shannon, Kathleen M. ;
Keshavarzian, Ali ;
Dodiya, Hemraj B. ;
Jakate, Shriram ;
Kordower, Jeffrey H. .
MOVEMENT DISORDERS, 2012, 27 (06) :716-719
[90]   Calcitriol protection against dopamine loss induced by intracerebroventricular administration of 6-hydroxydopamine [J].
Smith, Michael P. ;
Fletcher-Turner, Anita ;
Yurek, David M. ;
Cass, Wayne A. .
NEUROCHEMICAL RESEARCH, 2006, 31 (04) :533-539
234567891011