Immunosuppressive Drugs and Tregs: A Critical Evaluation!

被引：59
作者：
De Serres, Sacha A.
Sayegh, Mohamed H.
Najafian, Nader [1 ]
机构：
[1] Brigham & Womens Hosp, Div Renal, Transplantat Res Ctr, Boston, MA 02115 USA
来源：
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2009年 / 4卷 / 10期
基金：
美国国家卫生研究院;
关键词：
REGULATORY T-CELLS; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; CLINICAL TRANSPLANTATION TOLERANCE; TRANSCRIPTION FACTOR FOXP3; KIDNEY ALLOGRAFT PATIENTS; CALCINEURIN INHIBITORS; CUTTING EDGE; TGF-BETA; IN-VITRO; LYMPHOCYTE SUBPOPULATIONS;
D O I：
10.2215/CJN.03180509
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
To define therapeutic strategies that promote tolerance, it is of critical importance to determine the effects of immunosuppressive drugs on regulatory T cells (Tregs). This review discusses the current knowledge about the physiology of Tregs in humans, the role or Tregs in transplantation, and the impact of the different types of immunosuppressive agents on the frequency and functionality of Tregs in in vitro and in vivo systems. Clin J Am Soc Nephrol 4: 1661-1669, 2009. doi: 10.2215/CJN.03180509
引用
收藏
页码：1661 / 1669
页数：9
相关论文
共 86 条
[1]   CD4+ T-regulatory cells:: toward therapy for human diseases [J].
Allan, Sarah E. ;
Broady, Raewyn ;
Gregori, Silvia ;
Himmel, Megan E. ;
Locke, Natasha ;
Roncarolo, Maria Grazia ;
Bacchetta, Rosa ;
Levings, Megan K. .
IMMUNOLOGICAL REVIEWS, 2008, 223 :391-421
[2]   The arduous road to achieving an immunosuppression-free state in kidney transplant recipients [J].
Ansari, M. Javeed ;
Sayegh, Mohamed H. .
NATURE CLINICAL PRACTICE NEPHROLOGY, 2007, 3 (09) :464-465
[3]   Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin in human on the induction of FOXP3 T cells [J].
Baan, CC ;
van der Mast, BJ ;
Klepper, M ;
Mol, WM ;
Peeters, AMA ;
Korevaar, SS ;
Balk, AHMM ;
Weimar, W .
TRANSPLANTATION, 2005, 80 (01) :110-117
[4]   CD4+CD25high regulatory cells in human peripheral blood [J].
Baecher-Allan, C ;
Brown, JA ;
Freeman, GJ ;
Hafler, DA .
JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1245-1253
[5]   Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells [J].
Battaglia, M ;
Stabilini, A ;
Roncarolo, MG .
BLOOD, 2005, 105 (12) :4743-4748
[6]   Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients [J].
Battaglia, Manuela ;
Stabilini, Angela ;
Migliavacca, Barbara ;
Horejs-Hoeck, Jutta ;
Kaupper, Thomas ;
Roncarolo, Maria-Grazia .
JOURNAL OF IMMUNOLOGY, 2006, 177 (12) :8338-8347
[7]   The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 [J].
Bennett, CL ;
Christie, J ;
Ramsdell, F ;
Brunkow, ME ;
Ferguson, PJ ;
Whitesell, L ;
Kelly, TE ;
Saulsbury, FT ;
Chance, PF ;
Ochs, HD .
NATURE GENETICS, 2001, 27 (01) :20-21
[8]   All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation [J].
Benson, Micah J. ;
Pino-Lagos, Karina ;
Rosemblatt, Mario ;
Noelle, Randolph J. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1765-1774
[9]   Achieving donor-specific hyporesponsiveness is associated with FOXP3+ regulatory T cell recruitment in human renal allograft infiltrates [J].
Bestard, Oriol ;
Cruzado, Josep M. ;
Mestre, Mariona ;
Caldes, Anna ;
Bas, Jordi ;
Carrera, Marta ;
Torras, Joan ;
Rama, Ines ;
Moreso, Francesc ;
Seron, Daniel ;
Grinyo, Josep M. .
JOURNAL OF IMMUNOLOGY, 2007, 179 (07) :4901-4909
[10]   CD4+CD25+FOXP3+ regulatory t cells increase De novo in kidney transplant patients after immunodepletion with Campath-1H [J].
Bloom, D. D. ;
Chang, Z. ;
Fechner, J. H. ;
Dar, W. ;
Polster, S. P. ;
Pascual, J. ;
Turka, L. A. ;
Knechtle, S. J. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (04) :793-802
123456789