From One to Many: Further Refinement of Medulloblastoma Subtypes Offers Promise for Personalized Therapy

被引：10

作者：

Bavle, Abhishek ^{[1
,2
]}

Parsons, D. Williams ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Hematol Oncol Sect, Dept Pediat, Houston, TX 77030 USA

[2] Texas Childrens Canc Ctr, Houston, TX 77030 USA

来源：

CANCER CELL | 2017年 / 31卷 / 06期

关键词：

CHEMOTHERAPY;

D O I：

10.1016/j.ccell.2017.05.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is significant intertumoral heterogeneity within the four molecular subgroups of medulloblastoma. In this issue of Cancer Cell, Cavalli et al. apply similarity network fusion to gene expression and DNA methylation data to identify 12 medulloblastoma subtypes with distinct molecular and clinical profiles, making an important step toward molecularly tailored therapy.

引用

页码：727 / 729

页数：3

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