BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson's disease

被引：63
作者：
Guerini, F. R. [1 ]
Beghi, E. [1 ,2 ]
Riboldazzi, G. [3 ]
Zangaglia, R. [4 ]
Pianezzola, C. [5 ]
Bono, G. [5 ]
Casali, C. [6 ]
Di Lorenzo, C. [6 ]
Agliardi, C. [1 ]
Nappi, G. [7 ]
Clerici, M. [1 ,9 ]
Martignoni, E. [8 ,10 ,11 ]
机构：
[1] Don C Gnocchi Fdn IRCCS, Lab Mol Med & Biotechnol, Milan, Italy
[2] Mario Negri Inst Pharmacol Res, Lab Neurol Disorders, Milan, Italy
[3] Osped Circolo & Fdn Macchi, Ctr Parkinsons Dis & Movement Disorders, Varese, Italy
[4] IRCCS Neurol Inst C Mondino, Parkinsons Dis & Movement Disorders Unit, Pavia, Italy
[5] Univ Insubria, Dept Neurol, Varese, Italy
[6] IRCCS Neurol Inst C Mondino, Mol Neurogenet Lab, Rome, Italy
[7] Univ Roma La Sapienza, Dept Neurol & Otorhinolaryngol, Rome, Italy
[8] IRCCS Neurol Inst C Mondino, Interdepartmental Res Ctr Parkinsons Dis, Pavia, Italy
[9] Univ Milan, Dept Biomed Sci & Technol, I-20133 Milan, Italy
[10] Univ Piemonte Orientale, Dept Clin & Expt Med, Novara, Italy
[11] Sci Inst Veruno, Unit Neurorehabil & Movement Disorders, IRCCS Maugeri, Novara, Italy
来源：
EUROPEAN JOURNAL OF NEUROLOGY | 2009年 / 16卷 / 11期
关键词：
Brain Derived Neurotrophic Factor; Mini Mental State Examination; Parkinson's disease; NEUROTROPHIC FACTOR GENE; ALZHEIMERS-DISEASE; HUMAN BRAIN; DEMENTIA; ONSET; VARIANTS; RISK; AGE;
D O I：
10.1111/j.1468-1331.2009.02706.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background and purpose: A possible association between Parkinson's disease (PD) and the polymorphism of Brain Derived Neurotrophic Factor (BDNF) G196A (Val66Met) has been suggested by different studies that nevertheless yielded-contrasting result. The purpose of this study was to analyze such possible association in a cohort of Italian PD patients. Methods: The BDNF polymorphisms were analyzed in 294 Italian patients with PD; results were compared to those obtained in 233 age- and sex-matched healthy controls (HC) enrolled from two tertiary centres in Italy. Polymorphisms were determined by Restriction Fragment Length Polymorphism (RFLP) analysis; correlations between BDNF G196A polymorphism, and cognitive function were established by sub analyzing the results upon dividing PD patients based on their Mini Mental State Examination (MMSE) score. Results: Univariate analysis showed a highly significant correlation between the BDNF(AA) genotype and a MMSE score < 24. Hence, the distribution of this genotype in PD individuals with a MMSE score < 24 was significantly increased compared to PD patients with an MMSE score > 24 and HC (P < 0.001 in both cases). Multivariate analyses showed that BDNF (AA) genotype was associated to a sixfold risk of cognitive impairment. Conclusions: The BDNF(AA) homozygote genotype is over-represented in PD patients compared with normal individuals; this genotype was significantly correlated to cognitive impairment, age and disease severity. These results, although preliminary, could be important in establishing novel diagnostic and therapeutic approaches to PD.
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收藏
页码：1240 / 1245
页数：6
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