Tolerance and stress response to ethanol in the yeast Saccharomyces cerevisiae

被引:229
作者
Ding, Junmei [1 ,2 ]
Huang, Xiaowei [1 ,2 ]
Zhang, Lemin [1 ,2 ]
Zhao, Na [1 ,2 ]
Yang, Dongmei [1 ,2 ]
Zhang, Keqin [1 ,2 ]
机构
[1] Yunnan Univ, Lab Conservat & Utilizat Bioresources, Minist Educ, Kunming 650091, Yunnan, Peoples R China
[2] Yunnan Univ, Key Lab Microbial Resources, Minist Educ, Kunming 650091, Yunnan, Peoples R China
关键词
Ethanol tolerance; Stress response; Membrane composition; Stabilization of proteins; Regulation of gene expression; SHOCK TRANSCRIPTION FACTOR; L-PROLINE ACCUMULATION; MEMBRANE H+-ATPASE; HEAT-SHOCK; IN-VIVO; TREHALOSE ACCUMULATION; ELEMENT STRE; SAKE YEAST; TREHALOSE-6-PHOSPHATE SYNTHASE; NUCLEAR-LOCALIZATION;
D O I
10.1007/s00253-009-2223-1
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Eukaryotic cells have developed diverse strategies to combat the harmful effects of a variety of stress conditions. In the model yeast Saccharomyces cerevisiae, the increased concentration of ethanol, as the primary fermentation product, will influence the membrane fluidity and be toxic to membrane proteins, leading to cell growth inhibition and even death. Though little is known about the complex signal network responsible for alcohol stress responses in yeast cells, several mechanisms have been reported to be associated with this process, including changes in gene expression, in membrane composition, and increases in chaperone proteins that help stabilize other denatured proteins. Here, we review the recent progresses in our understanding of ethanol resistance and stress responses in yeast.
引用
收藏
页码:253 / 263
页数:11
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