Obesity and Acute Lung Injury

被引:61
作者
McCallister, JenniferW. [1 ]
Adkins, Eric J. [1 ]
O'Brien, James M., Jr. [1 ]
机构
[1] Ohio State Univ, Med Ctr, Div Pulm Allergy Crit Care & Sleep Med, Ctr Crit Care, Columbus, OH 43210 USA
关键词
Acute lung injury; Acute respiratory distress syndrome; Obesity; Mechanical ventilation; Critical care; Disparities of care; Adiponectin; RESPIRATORY-DISTRESS-SYNDROME; BODY-MASS INDEX; VON-WILLEBRAND-FACTOR; INTRAOPERATIVE ARTERIAL OXYGENATION; MECHANICALLY VENTILATED PATIENTS; RANDOMIZED CONTROLLED-TRIAL; EXPIRATORY FLOW LIMITATION; LEFT-VENTRICULAR FUNCTION; INDEPENDENT RISK-FACTOR; PULMONARY-EDEMA FLUID;
D O I
10.1016/j.ccm.2009.05.008
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are common indications for ICU admission and mechanical ventilation. AWARDS also consumes significant health care resources and is a common cause of death in ICU patients. Obesity produces changes in respiratory system physiology that could affect outcomes for AWARDS patients and their response to treatment. Additionally, the biochemical alterations seen in obese patients, such as increased inflammation and altered metabolism, could affect the risk of developing ALI/ARDS in patients with another risk factor (eg, sepsis). The few studies that have examined the influence of obesity on the outcomes from AWARDS are inconclusive. Furthermore, observed results could be biased by disparities in provided care.
引用
收藏
页码:495 / +
页数:15
相关论文
共 105 条
[1]   THE RELATIONSHIP OF OBESITY TO THE FREQUENCY OF PELVIC EXAMINATIONS - DO PHYSICIAN AND PATIENT ATTITUDES MAKE A DIFFERENCE [J].
ADAMS, CH ;
SMITH, NJ ;
WILBUR, DC ;
GRADY, KE .
WOMEN & HEALTH, 1993, 20 (02) :45-57
[2]   Leptin [J].
Ahima, RS ;
Flier, JS .
ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 :413-437
[3]   Cardiac morphology and left ventricular function in normotensive morbidly obese patients with and without congestive heart failure, and effect of weight loss [J].
Alpert, MA ;
Terry, BE ;
Mulekar, M ;
Cohen, MV ;
Massey, CV ;
Fan, TM ;
Panayiotou, H ;
Mukerji, V .
AMERICAN JOURNAL OF CARDIOLOGY, 1997, 80 (06) :736-740
[4]   RELATION OF DURATION OF MORBID-OBESITY TO LEFT-VENTRICULAR MASS, SYSTOLIC FUNCTION, AND DIASTOLIC FILLING, AND EFFECT OF WEIGHT-LOSS [J].
ALPERT, MA ;
LAMBERT, CR ;
PANAYIOTOU, H ;
TERRY, BE ;
COHEN, MV ;
MASSEY, CV ;
HASHIMI, MW ;
MUKERJI, V .
AMERICAN JOURNAL OF CARDIOLOGY, 1995, 76 (16) :1194-+
[5]  
[Anonymous], 1998, OBES RES S, V2, p51s
[6]   Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].
Arita, Y ;
Kihara, S ;
Ouchi, N ;
Takahashi, M ;
Maeda, K ;
Miyagawa, J ;
Hotta, K ;
Shimomura, I ;
Nakamura, T ;
Miyaoka, K ;
Kuriyama, H ;
Nishida, M ;
Yamashita, S ;
Okubo, K ;
Matsubara, K ;
Muraguchi, M ;
Ohmoto, Y ;
Funahashi, T ;
Matsuzawa, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83
[7]   Relationship of plasma leptin to plasma cytokines and human survival in sepsis and septic shock [J].
Arnalich, F ;
López, J ;
Codoceo, R ;
Jiménez, M ;
Madero, R ;
Montiel, C .
JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (03) :908-911
[8]   Mechanisms of endothelial dysfunction in obesity [J].
Avogaro, A ;
de Kreutzenberg, SV .
CLINICA CHIMICA ACTA, 2005, 360 (1-2) :9-26
[9]  
BACHOFEN M, 1982, CLIN CHEST MED, V3, P35
[10]  
BARRERA F, 1973, AM REV RESPIR DIS, V108, P819