Recent progress in discovery and development of antimitotic agents

被引：46
作者：
Kiselyov, Alex
Balakin, Konstantin V.
Tkachenko, Sergey E.
Savchuk, Nikolay
Ivachtchenko, Alexandre V.
机构：
[1] ChemDiv. Inc., San Diego, CA 92121
来源：
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 02期
关键词：
Antimitotic agent; Inhibitor of tubulin polymerization; Microtubule-stabilizing agent; Mitotic kinase; Mitotic kinesin;
D O I：
10.2174/187152007780058650
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This review highlights structural diversity of antimitotic agents. In particular, we emphasized current antimitotic therapies based on modulation of microtubule dynamics. With several successful anticancer drugs on the market and numerous compounds in clinical developments, tubulin-binding agents remain among the most important categories of anticancer agents. Compounds targeting mitotic kinases and kinesins are also discussed.
引用
收藏
页码：189 / 208
页数：20
相关论文
共 177 条
[41]   Peloruside A does not bind to the taxoid site on β-tubulin and retains its activity in multidrug-resistant cell lines [J].
Gaitanos, TN ;
Buey, RM ;
Díaz, JF ;
Northcote, PT ;
Teesdale-Spittle, P ;
Andreu, JM ;
Miller, JH .
CANCER RESEARCH, 2004, 64 (15) :5063-5067
[42]  
Galmarini CM, 2003, IDRUGS, V6, P1182
[43]   A phase I study of T900607 given once every 3 weeks in patients with advanced refractory cancers; National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG) IND 130 [J].
Gelmon, KA ;
Belanger, K ;
Soulieres, D ;
Britten, C ;
Chia, S ;
Charpentier, D ;
Chi, K ;
Powers, J ;
Walsh, W ;
Seymour, L .
INVESTIGATIONAL NEW DRUGS, 2005, 23 (05) :445-453
[44]   Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization [J].
Giannakakou, P ;
Sackett, DL ;
Kang, YK ;
Zhan, ZR ;
Buters, JTM ;
Fojo, T ;
Poruchynsky, MS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (27) :17118-17125
[45]   ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent [J].
Gumireddy, K ;
Reddy, MVR ;
Cosenza, SC ;
Nathan, RB ;
Baker, SJ ;
Papathi, N ;
Jiang, JD ;
Holland, J ;
Reddy, EP .
CANCER CELL, 2005, 7 (03) :275-286
[46]   Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: Preparation and biological activity [J].
Gunasekera, SP ;
Longley, RE ;
Isbrucker, RA .
JOURNAL OF NATURAL PRODUCTS, 2002, 65 (12) :1830-1837
[47]   Five new discodermolide analogues from the marine sponge Discodermia species [J].
Gunasekera, SP ;
Paul, GK ;
Longley, RE ;
Isbrucker, RA ;
Pomponi, SA .
JOURNAL OF NATURAL PRODUCTS, 2002, 65 (11) :1643-1648
[48]  
GUNTHER E, 2004, Patent No. 6706722
[49]   Synthesis, in vitro, and in vivo evaluation of phosphate ester derivatives of combretastatin A-4 [J].
Hadimani, MB ;
Hua, JY ;
Jonklaas, MD ;
Kessler, RJ ;
Sheng, YZ ;
Olivares, A ;
Tanpure, RP ;
Weiser, A ;
Zhang, JX ;
Edvardsen, K ;
Kane, RR ;
Pinney, KG .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (09) :1505-1508
[50]  
HADIMANI MB, 2003, 226 ACS NATL M
12345678910