Recent progress in discovery and development of antimitotic agents

被引：46
作者：
Kiselyov, Alex
Balakin, Konstantin V.
Tkachenko, Sergey E.
Savchuk, Nikolay
Ivachtchenko, Alexandre V.
机构：
[1] ChemDiv. Inc., San Diego, CA 92121
来源：
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2007年 / 7卷 / 02期
关键词：
Antimitotic agent; Inhibitor of tubulin polymerization; Microtubule-stabilizing agent; Mitotic kinase; Mitotic kinesin;
D O I：
10.2174/187152007780058650
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This review highlights structural diversity of antimitotic agents. In particular, we emphasized current antimitotic therapies based on modulation of microtubule dynamics. With several successful anticancer drugs on the market and numerous compounds in clinical developments, tubulin-binding agents remain among the most important categories of anticancer agents. Compounds targeting mitotic kinases and kinesins are also discussed.
引用
收藏
页码：189 / 208
页数：20
相关论文
共 177 条
[1]  
AGOULNIK S, 2005, 41 ANN M AM SOC CLIN
[2]  
Al-awar RS, 2004, MOL CANCER THER, V3, P1061
[3]  
Aleksandrzak K, 1998, ANTI-CANCER DRUG, V9, P545
[4]   Epothilone B and its Analogs - A New Family of Anticancer Agents [J].
Altmann, Karl-Heinz .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2003, 3 (02) :149-158
[5]   AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol [J].
Anand, S ;
Penrhyn-Lowe, S ;
Venkitaraman, AR .
CANCER CELL, 2003, 3 (01) :51-62
[6]   Proteomic characterization of the human centrosome by protein correlation profiling [J].
Andersen, JS ;
Wilkinson, CJ ;
Mayor, T ;
Mortensen, P ;
Nigg, EA ;
Mann, M .
NATURE, 2003, 426 (6966) :570-574
[7]   Effects of rhizoxin, a microbial angiogenesis inhibitor, on angiogenic endothelial cell functions [J].
Aoki, K ;
Watanabe, K ;
Sato, M ;
Ikekita, M ;
Hakamatsuka, T ;
Oikawa, T .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2003, 459 (2-3) :131-138
[8]   Update on tubulin-binding agents [J].
Attard, G ;
Greystoke, A ;
Kaye, S ;
De Bono, J .
PATHOLOGIE BIOLOGIE, 2006, 54 (02) :72-84
[9]  
AYRALKALOUSTIAN S, 2005, 230 ACS NAT M
[10]   Polo-like kinases and the orchestration of cell division [J].
Barr, FA ;
Silljé, HHW ;
Nigg, EA .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (06) :429-440
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