Pyrazole-carboxaldehydes as versatile precursors for different pyrazole-substituted heterocyclic systems

被引：11

作者：

Abdelhamid, Ismail A. ^{[1
]}

Hawass, Mahmoud A. E. ^{[1
]}

Sanad, Sherif M. H. ^{[1
]}

Elwahy, Ahmed H. M. ^{[1
]}

机构：

[1] Cairo Univ, Fac Sci, Chem Dept, Giza, Egypt

来源：

ARKIVOC | 2021年

关键词：

Vilsmeier-Haack reaction; pyrazole-carboxaldehydes; pyrazole-substituted heterocycles; pyrazole-substituted fused-heterocycles; ONE-POT SYNTHESIS; DUAL ACTING ANTIMALARIAL; ACIDIC IONIC LIQUID; BIOLOGICAL EVALUATION; ANTIMICROBIAL ACTIVITIES; MULTICOMPONENT REACTIONS; POTENTIAL ANTICANCER; FUSED HETEROCYCLES; FACILE SYNTHESIS; CYTOTOXICITY EVALUATION;

D O I：

10.24820/ark.5550190.p011.404

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the last decade, interest in pyrazole chemistry has grown considerably due to the discovery of fascinating properties demonstrated by a large number of pyrazole derivatives. They occur in a wide range of natural products, dyes, and as scaffolds in a number of drugs and associated pharmaceutical active substances. Substantial attention has been paid to the creation of hybrid molecules in which two heterocycles are bound in a single molecule to enhance their biological effectiveness and overcome drug resistance. In this regard, this review illustrated various methods for the construction of pyrazole-substituted heterocycles and their corresponding fused derivatives using pyrazole carboxaldehydes as effective precursors. The heterocyclic systems mentioned in this review are categorized according to the type of the heterocyclic systems. [GRAPHICS] .

引用

页码：162 / 235

页数：74

共 241 条

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[2]

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