Catalytic asymmetric alkylation of α-cyanocarboxylates and acetoacetates using a phase-transfer catalyst

被引：29

作者：

Nagata, Kazuhiro ^{[1
]}

Sano, Daisuke ^{[1
]}

Shimizu, Yu ^{[1
]}

Miyazaki, Michiko ^{[1
]}

Kanemitsu, Takuya ^{[1
]}

Itoh, Takashi ^{[1
]}

机构：

[1] Showa Univ, Sch Pharmaceut Sci, Shinagawa Ku, Tokyo 1428555, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2009年 / 20卷 / 21期

关键词：

BETA-KETO-ESTERS; CARBON QUATERNARY STEREOCENTERS; AMINO-ACIDS; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE SYNTHESIS; NATURAL-PRODUCTS; AMMONIUM-SALTS; SCHIFF-BASE; CONSTRUCTION; (-)-PHYSOSTIGMINE;

D O I：

10.1016/j.tetasy.2009.10.018

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The catalytic asymmetric alkylation of alpha-cyanocarboxylates and acetoacetates with an alkyl halide was performed under phase-transfer conditions to afford compounds which have a chiral quaternary carbon with up to 97% and 94% ee, respectively. As applications of this method, chiral 2-oxindole derivatives and a beta-lactam derivative were synthesized. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2530 / 2536

页数：7

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