Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats

被引:15
作者
Emmanuel Santana-Gomez, Cesar [1 ]
Adela Orozco-Suarez, Sandra [2 ]
Talevi, Alan [3 ]
Bruno-Blanch, Luis [3 ]
Manuel Magdaleno-Madrigal, Victor [4 ]
Fernandez-Mas, Rodrigo [4 ]
Rocha, Luisa [1 ]
机构
[1] Ctr Res & Adv Studies CINVESTAV, Dept Pharmacobiol, Mexico City, DF, Mexico
[2] Natl Med Ctr SXXI CMN SXXI, Specialties Hosp, Unit Med Res Neurol Dis, Mexico City, DF, Mexico
[3] Natl Univ La Plata, Fac Exact Sci, Dept Biol Sci, Med Chem, Buenos Aires, DF, Argentina
[4] Natl Inst Psychiat Ramon de la Fuente Muniz, Dept Neurosci Res, Mexico City, DF, Mexico
关键词
Neuroprotection; Glutamate; Cell damage; Electrographic activity; Neuronal excitability; FOCAL ELECTRICAL-STIMULATION; GAMMA-AMINOBUTYRIC-ACID; BREAST-CANCER CELLS; ESTROGENIC ACTIVITY; NEURONAL DAMAGE; ESTRADIOL PROTECTS; PROPYL PARABEN; MODEL; EXPRESSION; RECEPTOR;
D O I
10.1016/j.neuro.2017.01.009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Propylparaben (PPB) induces cardioprotection after ischemia-reperfusion injury by inhibiting voltage dependent Na channels. The present study focuses on investigating whether the i.p. application of 178 mg/kg PPB after pilocarpine-induced status epilepticus (SE) reduces the acute and long-term consequences of seizure activity. Initially, we investigated the effects of a single administration of PPB after SE. Our results revealed that compared to rats receiving diazepam (DZP) plus vehicle after 2 h of SE, animals receiving a single dose of PPB 1 h after DZP injection presented 126% (p < 0.001) lower extracellular levels of glutamate in the hippocampus. This effect was associated with an increased potency of low-frequency oscillations (0.1-13 Hz bands, p < 0.001), a reduced potency of 30-250 Hz bands (p < 0.001) and less neuronal damage in the hippocampus. The second experiment examined whether the subchronic administration of PPB during the post-SE period is able to prevent the long-term consequences of seizure activity. In comparison to animals that were treated subchronically with vehicle after SE, rats administered with PPB for 5 days presented lower hippocampal excitability and interictal glutamate release, astrogliosis, and neuroprotection in the dentate gyrus. Our data indicate that PPB, when applied after SE, can be used as a therapeutic strategy to reduce the consequences of seizure activity. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码:110 / 120
页数:11
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