Zn-Mediated, Pd-Catalyzed Cross-Couplings in Water at Room Temperature Without Prior Formation of Organozinc Reagents

被引：217
作者：
Krasovskiy, Arkady [1 ]
Duplais, Christophe [1 ]
Lipshutz, Bruce H. [1 ]
机构：
[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 43期
关键词：
AQUEOUS-MEDIA; CONJUGATE ADDITIONS; CARBONYL-COMPOUNDS; ORGANIC-SYNTHESIS; ZINC; ULTRASOUND; PALLADIUM; REACTIVITY; HALOARYLS; HALIDES;
D O I：
10.1021/ja906803t
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mix in water, stir. That is all that is required in this new approach to sp(3)-sp(2) cross-couplings between an alkyl iodide and an aryl bromide, both potentially bearing functionality. They react under catalysis by Pd(0) in the presence of zinc powder, aided by a nonionic amphiphile, to give the alkylated aromatic. No organic solvents and no heating; just add water.
引用
收藏
页码：15592 / +
页数：3
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