Synthetic approaches to radiochemical probes for imaging of bacterial infections

被引：21

作者：

Dutta, Jyotibon ^{[1
]}

Naicker, Tricia ^{[1
]}

Ebenhan, Thomas ^{[2
,3
]}

Kruger, Hendrik G. ^{[1
]}

Arvidsson, Per I. ^{[1
,4
,5
]}

Govender, Thavendran ^{[1
]}

机构：

[1] Univ KwaZulu Natal, Sch Hlth Sci, Catalysis & Peptide Res Unit, ZA-4001 Durban, South Africa

[2] Univ Pretoria, Crn Malherbe & Steve Biko Rd, ZA-0001 Pretoria, South Africa

[3] Steve Biko Acad Hosp, Crn Malherbe & Steve Biko Rd, ZA-0001 Pretoria, South Africa

[4] Karolinska Inst, Sci Life Lab, Drug Discovery & Dev Platform, Dept Med Biochem & Biophys, SE-17177 Stockholm, Sweden

[5] Karolinska Inst, Div Translat Med & Chem Biol, Dept Med Biochem & Biophys, SE-17177 Stockholm, Sweden

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2017年 / 133卷

关键词：

WHITE CELL SCINTIGRAPHY; STAPHYLOCOCCUS-AUREUS INFECTION; POSITRON-EMISSION-TOMOGRAPHY; IN-VITRO; ANTIMICROBIAL PEPTIDES; BIOLOGICAL EVALUATION; ESCHERICHIA-COLI; HUMAN BETA-DEFENSIN-3; DETECTING SITES; ANTIBACTERIAL ACTIVITY;

D O I：

10.1016/j.ejmech.2017.03.060

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This present review provides an account on the available synthetic strategies employed to radiolabel commercial and potential bacteria-selective probes for tomographic imaging. These molecular probes encompass leukocytes, antibodies, small molecules, peptides, antibiotics, macrolides, vitamins, oligomers and siderophores. Although this technique has shown to be a valuable tool for non-invasive infection imaging, more development is required to create easy-to-radiolabel kit solutions procedures for the preparation of the probes. (C) 2017 Elsevier Masson SAS. All rights reserved.

引用

页码：287 / 308

页数：22

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