Disproportionation reaction of diarylmethylisopropyl ethers: a versatile access to diarylmethanes from diarylcarbinols speeded up by the use of microwave irradiation

被引：35

作者：

L'Hermite, Nathalie ^{[1
]}

Giraud, Anne ^{[1
]}

Provot, Olivier ^{[1
]}

Peyrat, Jean-Francois ^{[1
]}

Alami, Mouad ^{[1
]}

Brion, Jean-Daniel ^{[1
]}

机构：

[1] Univ Paris Sud, Fac Pharm, CNRS, Chim Therapeut Lab,BioCIS,UMR 8076, F-92296 Chatenay Malabry, France

来源：

TETRAHEDRON | 2006年 / 62卷 / 51期

关键词：

disproportionation; diarylcarbinols; diarylmethanes; i-PrOH; CBr4; TfOH; microwave heating;

D O I：

10.1016/j.tet.2006.09.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of diarylmethanes under classical thermal conditions and under microwave heating is described from diarylcarbinols via a new disproportionation reaction. The key step involves a selective hydride transfer of isopropyl ether intermediates. Mild reaction conditions i.e., catalytic CBr4 or TfOH in i-PrOH and good yields render this method useful and competitive to the conventional approaches relying on application of external reducing agents. (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：11994 / 12002

页数：9

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