How physiologically based pharmacokinetic models should be improved for drug development

被引：1
|
作者：
Hempel, Georg [1 ]
机构：
[1] Westfal Wilheims Univ Munster, Inst Pharmazeut & Med Chem, Klin Pharm, Corrensstr 48, D-48149 Munster, Germany
来源：
FUTURE MEDICINAL CHEMISTRY | 2020年 / 12卷 / 12期
关键词：
antimicrobial drugs; drug development; drug metabolism; infectious disease therapeutics; pharmacokinetics/pharmacodynamics; pharmacology; systems biology; A-PRIORI; KINETICS;
D O I：
10.4155/fmc-2020-0074
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：1107 / 1109
页数：3
相关论文
共 50 条
  • [41] Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone
    Chen, Yuan
    Mao, Jialin
    Hop, Cornelis E. C. A.
    DRUG METABOLISM AND DISPOSITION, 2015, 43 (02) : 182 - 189
  • [42] A Physiologically Based Modeling Strategy during Preclinical CNS Drug Development
    Ball, Kathryn
    Bouzom, Francois
    Scherrmann, Jean-Michel
    Walther, Bernard
    Decleves, Xavier
    MOLECULAR PHARMACEUTICS, 2014, 11 (03) : 836 - 848
  • [43] Dose Selection Based on Physiologically Based Pharmacokinetic (PBPK) Approaches
    Jones, Hannah M.
    Mayawala, Kapil
    Poulin, Patrick
    AAPS JOURNAL, 2013, 15 (02): : 377 - 387
  • [44] A Physiologically Based Pharmacokinetic Model for Strontium Exposure in Rat
    Pertinez, Henry
    Chenel, Marylore
    Aarons, Leon
    PHARMACEUTICAL RESEARCH, 2013, 30 (06) : 1536 - 1552
  • [45] The Role of Physiologically Based Pharmacokinetic Modeling in Regulatory Review
    Huang, S-M
    Rowland, M.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2012, 91 (03) : 542 - 549
  • [46] Clinical relevance of predictive physiologically based pharmacokinetic methods
    Thomas, Simon
    EXPERT OPINION ON DRUG DISCOVERY, 2008, 3 (07) : 725 - 732
  • [47] Development of a Physiologically-Based Pharmacokinetic Model of Δ9-Tetrahydrocannabinol in Mice, Rats, and Pigs
    Methaneethorn, Janthima
    Naosang, Kanyamas
    Kaewworasut, Parichart
    Poomsaidorn, Chomkanang
    Lohitnavy, Manupat
    EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 45 (04) : 487 - 494
  • [48] Maternal-Fetal Pharmacology of Drugs: A Review of Current Status of the Application of Physiologically Based Pharmacokinetic Models
    Chaphekar, Nupur
    Dodeja, Prerna
    Shaik, Imam H.
    Caritis, Steve
    Venkataramanan, Raman
    FRONTIERS IN PEDIATRICS, 2021, 9
  • [49] Advancing Estimation of Hepatobiliary Clearances in Physiologically Based Pharmacokinetic Models of Rosuvastatin Using Human Hepatic Concentrations
    Wang, Li
    Zhu, Zhiyao
    Doanh Tran
    Seo, Shirley K.
    Pan, Xiaolei
    PHARMACEUTICAL RESEARCH, 2021, 38 (12) : 2035 - 2046
  • [50] Physiologically-based modeling of monoclonal antibody pharmacokinetics in drug discovery and development
    Glassman, Patrick M.
    Balthasar, Joseph P.
    DRUG METABOLISM AND PHARMACOKINETICS, 2019, 34 (01) : 3 - 13
12345