How physiologically based pharmacokinetic models should be improved for drug development

被引：1
|
作者：
Hempel, Georg [1 ]
机构：
[1] Westfal Wilheims Univ Munster, Inst Pharmazeut & Med Chem, Klin Pharm, Corrensstr 48, D-48149 Munster, Germany
来源：
FUTURE MEDICINAL CHEMISTRY | 2020年 / 12卷 / 12期
关键词：
antimicrobial drugs; drug development; drug metabolism; infectious disease therapeutics; pharmacokinetics/pharmacodynamics; pharmacology; systems biology; A-PRIORI; KINETICS;
D O I：
10.4155/fmc-2020-0074
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：1107 / 1109
页数：3
相关论文
共 50 条
  • [31] Physiologically Based Pharmacokinetic (PBPK) Modeling in Children
    Barrett, J. S.
    Alberighi, O. Della Casa
    Laeer, S.
    Meibohm, B.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2012, 92 (01) : 40 - 49
  • [32] Teaching of drug disposition using physiologically based pharmacokinetic modeling software: GastroPlus as an educational tool
    Morningstar-Kywi, Noam
    Morris, Denise N.
    Romero, Rebecca M.
    Haworth, Ian S.
    ADVANCES IN PHYSIOLOGY EDUCATION, 2023, 47 (04) : 718 - 725
  • [33] Physiologically Based Pharmacokinetic Modeling to Identify Physiological and Molecular Characteristics Driving Variability in Drug Exposure
    Rowland, Andrew
    van Dyk, Madele
    Hopkins, Ashley M.
    Mounzer, Reham
    Polasek, Thomas M.
    Rostami-Hodjegan, Amin
    Sorich, Michael J.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2018, 104 (06) : 1219 - 1228
  • [34] Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations
    Ke, Alice Ban
    Greupink, Rick
    Abduljalil, Khaled
    CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2018, 7 (02): : 103 - 110
  • [35] Physiologically-based pharmacokinetic modeling of target-mediated drug disposition of bortezomib in mice
    Zhang, Li
    Mager, Donald E.
    JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2015, 42 (05) : 541 - 552
  • [36] Development of a physiologically-based pharmacokinetic model to simulate the pharmacokinetics of intramuscular antiretroviral drugs
    Bettonte, Sara
    Berton, Mattia
    Battegay, Manuel
    Stader, Felix
    Marzolini, Catia
    CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2024, 13 (05): : 781 - 794
  • [37] Applications and prospects for physiologically based pharmacokinetic (PB-PK) models involving pharmaceutical agents
    Suzuki, H
    Iwatsubo, T
    Sugiyama, Y
    TOXICOLOGY LETTERS, 1995, 82-3 : 349 - 355
  • [38] Development and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients
    Kalam, Muhammad Nasir
    Rasool, Muhammad Fawad
    Alqahtani, Faleh
    Imran, Imran
    Rehman, Asim Ur
    Ahmed, Naveed
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 15 : 1195 - 1211
  • [39] The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development
    Keuper-Navis, Marit
    Walles, Markus
    Poller, Birk
    Myszczyszyn, Adam
    van der Made, Thomas K.
    Donkers, Joanne
    Amirabadi, Hossein Eslami
    Wilmer, Martijn J.
    Aan, Saskia
    Spee, Bart
    Masereeuw, Rosalinde
    van de Steeg, Evita
    PHARMACOLOGICAL RESEARCH, 2023, 195
  • [40] Semi-mechanistic physiologically-based pharmacokinetic modeling of clinical glibenclamide pharmacokinetics and drug-drug-interactions
    Greupink, Rick
    Schreurs, Marieke
    Benne, Marina S.
    Huisman, Maarten T.
    Russel, Frans G. M.
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2013, 49 (05) : 819 - 828
12345