Objective: To determine the frequency of stone clearance after multiple tract percutaneous nephrolithotomy for renal staghorn calculi Study Design: Descriptive case series Place and Duration of Study: Department of Urology, Shaikh Zayed Hospital, Lahore from 7th September 2016 to 7th March 2017. Methodology: One hundred patients with renal staghorn calculi of >20 mm in size and between 16 to 65 years of age were included. Multiple tract PCNL was done after completion of all investigations. All patients were given prophylactic antibiotics. Stone clearance post-operatively was assessed by CT-KUB. The stone free rate at 4 week interval was the endpoint of this study. Results: There were 65 (65%) males while 35 (35%) were females. Age range was from 16 to 65 years with mean age of 40.12 +/- 14.54 years. Mean size of the stone was 25.69 +/- 3.00 mm. Most of the patients 54(54%) had the size of stone >25 mm, while 46(46%) patients had the size of stone >25 mm. Overall success rate with multiple tract PCNL was 86% in patients with renal staghorn calculi. Conclusion: The multiple tracts PCNL is gold standard technique for staghorn calcului with reasonable operative duration, low morbidity and good success rate.