A primer of deuterium in drug design

被引:76
作者
Cargnin, Sarah [1 ]
Serafini, Marta [1 ]
Pirali, Tracey [1 ]
机构
[1] Univ Piemonte Orientale, Dept Pharmaceut Sci, Largo Donegani 2, I-28100 Novara, Italy
关键词
N-METHYL DEUTERATION; PHARMACOKINETICS;
D O I
10.4155/fmc-2019-0183
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:2039 / 2042
页数:4
相关论文
共 19 条
[1]  
[Anonymous], EU3192134 EUR MED AG
[2]   The renaissance of H/D exchange [J].
Atzrodt, Jens ;
Derdau, Volker ;
Fey, Thorsten ;
Zimmermann, Jochen .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (41) :7744-7765
[3]   The Pharmaceutical Industry in 2018. An Analysis of FDA Drug Approvals from the Perspective of Molecules [J].
de la Torre, Beatriz G. ;
Albericio, Fernando .
MOLECULES, 2019, 24 (04)
[4]   The Progression of Geographic Atrophy Secondary to Age-Related Macular Degeneration [J].
Fleckenstein, Monika ;
Mitchell, Paul ;
Freund, K. Bailey ;
Sadda, SriniVas ;
Holz, Frank G. ;
Brittain, Christopher ;
Henry, Erin C. ;
Ferrara, Daniela .
OPHTHALMOLOGY, 2018, 125 (03) :369-390
[5]   Using Deuterium in Drug Discovery: Leaving the Label in the Drug [J].
Gant, Thomas G. .
JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (09) :3595-3611
[6]   Differentiation of antiinflammatory and antitumorigenic properties of stabilized enantiomers of thalidomide analogs [J].
Jacques, Vincent ;
Czarnik, Anthony W. ;
Judge, Thomas M. ;
Van der Ploeg, Lex H. T. ;
DeWitt, Sheila H. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (12) :E1471-E1479
[7]   Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide [J].
Jiang, Jinfang ;
Pang, Xuehai ;
Li, Liang ;
Dai, Xiaojian ;
Diao, Xingxing ;
Chen, Xiaoyan ;
Zhong, Dafang ;
Wang, Yingwei ;
Chen, Yuanwei .
DRUG DESIGN DEVELOPMENT AND THERAPY, 2016, 10 :2181-2191
[8]   New clues to ancient water on Itokawa [J].
Jin, Ziliang ;
Bose, Maitrayee .
SCIENCE ADVANCES, 2019, 5 (05)
[9]   Deuterium Enrichment of Vitamin A at the C20 Position Slows the Formation of Detrimental Vitamin A Dimers in Wild-type Rodents [J].
Kaufman, Yardana ;
Ma, Li ;
Washington, Ilyas .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (10) :7958-7965
[10]   Aurora Kinase Inhibitors Based on the Imidazo[1,2-a]pyrazine Core Fluorine and Deuterium Incorporation Improve Oral Absorption and Exposure [J].
Kerekes, Angela D. ;
Esposite, Sara J. ;
Doll, Ronald J. ;
Tagat, Jayaram R. ;
Yu, Tao ;
Xiao, Yushi ;
Zhang, Yonglian ;
Prelusky, Dan B. ;
Tevar, Seema ;
Gray, Kimberly ;
Terracina, Gaby A. ;
Lee, Suining ;
Jones, Jennifer ;
Liu, Ming ;
Basso, Andrea D. ;
Smith, Elizabeth B. .
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 54 (01) :201-210