Administration of High-Dose Interleukin-2 in a 2-Year-Old With Metastatic Melanoma

被引：0

作者：

Bernhardt, M. Brooke ^{[1
]}

Hicks, M. John ^{[2
]}

Pappo, Alberto S. ^{[3
]}

机构：

[1] Texas Childrens Hosp, Dept Pharm, Houston, TX 77030 USA

[2] Texas Childrens Hosp, Dept Pathol, Houston, TX 77030 USA

[3] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

来源：

PEDIATRIC BLOOD & CANCER | 2009年 / 53卷 / 07期

关键词：

aldesleukin; melanoma; rare tumors; CHILDREN; INTERFERON-ALPHA-2B; THERAPY;

D O I：

10.1002/pbc.22255

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Malignant melanoma is rare in pediatrics, and therapies for patients with disseminated disease have not been well studied. This report describes our experience with the use of high-dose interleukin 2 (aldesleukin, IL-2) in a 2-year-old child with metastatic melanoma and describes our approach for the administration of this agent to young patients. Pediatr Blood Cancer 2009;53:1346-1348. (C) 2009 Wiley-Liss, Inc.

引用

页码：1346 / 1348

页数：3

共 11 条

[1] High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993 [J].

Atkins, MB ;

Lotze, MT ;

Dutcher, JP ;

Fisher, RI ;

Weiss, G ;

Margolin, K ;

Abrams, J ;

Sznol, M ;

Parkinson, D ;

Hawkins, M ;

Paradise, C ;

Kunkel, L ;

Rosenberg, SA .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (07) :2105-2116

[2]

CARNACHO LH, 2009, J CLIN ONCOL, V27, P1075

[3] CURRENT CONCEPTS - MELANOMA IN CHILDREN [J].

CEBALLOS, PI ;

RUIZMALDONADO, R ;

MIHM, MC .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (10) :656-662

[4]

COIT DG, 2009, NATL COMPREHENSIVE C

[5]

HOLMAN CDJ, 1984, JNCI-J NATL CANCER I, V72, P257

[6] Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: The Eastern Cooperative Oncology Group trial EST 1684 [J].

Kirkwood, JM ;

Strawderman, MH ;

Ernstoff, MS ;

Smith, TJ ;

Borden, EC ;

Blum, RH .

JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (01) :7-17

[7] Melanoma in children and teenagers: An analysis of patients from the National Cancer Data Base [J].

Lange, Julie R. ;

Palis, Bryan E. ;

Chang, David C. ;

Soong, Seng-Jaw ;

Balch, Charles M. .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (11) :1363-1368

[8]

*LEX COMP INC, 2009, LEX COMP ONL PED LEX

[9] The feasibility of adjuvant interferon α-2b in children with high-risk melanoma [J].

Navid, F ;

Furman, WL ;

Fleming, M ;

Rao, BN ;

Kovach, S ;

Billups, CA ;

Cain, AM ;

Amonette, R ;

Jenkins, JJ ;

Pappo, AS .

CANCER, 2005, 103 (04) :780-787

[10] Guidelines for the safe administration of high-dose interleukin-2 [J].

Schwartzentruber, DJ .

JOURNAL OF IMMUNOTHERAPY, 2001, 24 (04) :287-293

← 1 2 →