Protective effects of granulocyte colony-stimulating factor on endotoxin shock in mice with retrovirus-induced immunodeficiency syndrome

被引：3
|
作者：
Toki, S
Hiromatsu, K
Aoki, Y
Makino, M
Yoshikai, Y
机构：
[1] NAGOYA UNIV,SCH MED,DIS MECHANISM & CONTROL RES INST,HOST DEF LAB,SHOWA KU,NAGOYA,AICHI 466,JAPAN
[2] KAGOSHIMA UNIV,FAC ENGN,DIV HUMAN RETROVIRUS,CTR CHRON VIRAL DIS,KAGOSHIMA 890,JAPAN
来源：
CYTOKINE | 1997年 / 9卷 / 10期
关键词：
cytokines; endotoxin shock; G-CSF; MAIDS mice;
D O I：
10.1006/cyto.1997.0231
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mice with retrovirus-induced murine acquired immunodeficiency syndrome (MAIDS) were hypersensitive to lipopolysaccharide (LPS)-induced lethal shock accompanied by marked elevations of systemic interleukin 1 beta (IL-beta) and interferon gamma (IFN-gamma) after LPS challenge. Pretreatment with 10 mu g of recombinant human granulocyte colony-stimulating factor (rhG-CSF) protected MAIDS mice from hypersensitivity to LPS-induced lethal shock and this protection was concomitant with suppression of IFN-gamma production. (C) 1997 Academic Press Limited.
引用
收藏
页码：781 / 786
页数：6
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