Characterization of human stellate cell activation-associated protein and its expression in human liver

被引：33

作者：

Asahina, K

Kawada, N

Kristensen, DB

Nakatani, K

Seki, S

Shiokawa, M

Tateno, C

Obara, M

Yoshizato, K

机构：

[1] Hiroshima Univ, Grad Sch Sci, Dept Biol Sci, Dev Biol Lab, Hiroshima 7398526, Japan

[2] Japan Sci & Technol Corp, Hiroshima Prefecture Collaborat Reg Entit Advance, Tissue Regenerat Project, Hiroshima, Japan

[3] Osaka City Univ, Grad Sch Med, Dept Hepatol, Osaka 558, Japan

[4] Reg Sci Program Hiroshima Ind Technol Org, Hiroshima Proteome Lab, Hiroshima, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2002年 / 1577卷 / 03期

关键词：

globin; heme; hepatitis; lipid hydroperoxide peroxidase; mycloperoxidase;

D O I：

10.1016/S0167-4781(02)00477-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study cloned cDNA of human homologue (hSTAP) of rat stellate cell activation-associated protein (rSTAP). hSTAP gene is on chromosome 17q and is composed of four exons. Various types of cells including hepatic stellate cells expressed hSTAP mRNA. Recombinant hSTAP was a heme protein with the activity of peroxidase. hSTAP can be used as a marker of quiescent stellate cells in human liver. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：471 / 475

页数：5

共 13 条

[1] Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver [J].