A polymer-assisted solution-phase strategy for the synthesis of fused [2,1-b]quinazolinones and the preparation of optically active vasicinone

被引：20

作者：

Kamal, Ahmed ^{[1
]}

Devaiah, V. ^{[1
]}

Shankaraiah, N. ^{[1
]}

Reddy, K. Laxma ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNLETT | 2006年 / 16期

关键词：

polymer-supported reagents; fused [2,1-b]quinazolinones; oxidations; vasicinone;

D O I：

10.1055/s-2006-951482

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient preparation of fused [2,1-b]quinazolinones has been developed utilizing polymer-supported reagents. (+/-)Vasicitione was converted into its dione by oxidation with poly (4-vinylpyridiniumdichromate). An efficient method has been developed for the synthesis of (d)- and (l)-vasicinone via asymmetric reduction of pyrrolo[2,1-b]quinazoline-3,9-dione by employing NaBH4/Me3SiCl as the reducing agent and polymer-supported chiral sulfonamide as catalyst.

引用

页码：2609 / 2612

页数：4