The exon junction complex as a node of post-transcriptional networks

被引：198

作者：

Le Hir, Herve ^{[1
]}

Sauliere, Jerome

Wang, Zhen

机构：

[1] ENS, IBENS, F-75005 Paris, France

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2016年 / 17卷 / 01期

关键词：

MESSENGER-RNA DECAY; NONSENSE-MEDIATED DECAY; INTRON-CONTAINING TRANSCRIPTS; INITIATION-FACTOR; 4A3; MAGO-NASHI; CRYSTAL-STRUCTURE; BINDING PROTEIN; GENE-EXPRESSION; CORE COMPLEX; MAMMALIAN-CELLS;

D O I：

10.1038/nrm.2015.7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a unique structure, which can both stably bind to mRNAs and function as an anchor for diverse processing factors. Recent findings revealed that in addition to its established roles in nonsense-mediated mRNA decay, the EJC is involved in mRNA splicing, transport and translation. While structural studies have shed light on EJC assembly, transcriptome-wide analyses revealed differential EJC loading at spliced junctions. Thus, the EJC functions as a node of post-transcriptional gene expression networks, the importance of which is being revealed by the discovery of increasing numbers of EJC-related disorders.

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收藏

页码：41 / 54

页数：14

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