The exon junction complex as a node of post-transcriptional networks

被引：188
作者：
Le Hir, Herve [1 ]
Sauliere, Jerome
Wang, Zhen
机构：
[1] ENS, IBENS, F-75005 Paris, France
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2016年 / 17卷 / 01期
关键词：
MESSENGER-RNA DECAY; NONSENSE-MEDIATED DECAY; INTRON-CONTAINING TRANSCRIPTS; INITIATION-FACTOR; 4A3; MAGO-NASHI; CRYSTAL-STRUCTURE; BINDING PROTEIN; GENE-EXPRESSION; CORE COMPLEX; MAMMALIAN-CELLS;
D O I：
10.1038/nrm.2015.7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a unique structure, which can both stably bind to mRNAs and function as an anchor for diverse processing factors. Recent findings revealed that in addition to its established roles in nonsense-mediated mRNA decay, the EJC is involved in mRNA splicing, transport and translation. While structural studies have shed light on EJC assembly, transcriptome-wide analyses revealed differential EJC loading at spliced junctions. Thus, the EJC functions as a node of post-transcriptional gene expression networks, the importance of which is being revealed by the discovery of increasing numbers of EJC-related disorders.
引用
收藏
页码：41 / 54
页数：14
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